Cationic and Neutral N‐Heterocyclic Carbene Gold(I) Complexes: Cytotoxicity, NCI‐60 Screening, Cellular Uptake, Inhibition of Mammalian Thioredoxin Reductase, and Reactive Oxygen Species Formation
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DOI: 10.1002/cmdc.201800181
Abstract: A structurally diverse library of 14 gold(I) cationic bis(NHC) and neutral mono(NHC) complexes (NHC: N‐heterocyclic carbene) was synthesized and characterized in this work. Four of them were new cationic gold(I) complexes containing functionalized NHCs, and… read more here.
Keywords: thioredoxin reductase; gold; cytotoxicity; gold complexes ... See more keywords
Small molecule inhibitors of mammalian thioredoxin reductase as potential anticancer agents: An update
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DOI: 10.1002/med.21507
Abstract: Mammalian thioredoxin reductase (TrxR) enzymes are homodimeric flavin proteins sharing a unique yet essential selenocysteine residue at their C‐terminus. TrxRs, together with their endogenous substrate thioredoxins, play a crucial role in regulating diverse cellular redox… read more here.
Keywords: thioredoxin reductase; molecule; inhibitors mammalian; small molecule ... See more keywords
The role of the thioredoxin/thioredoxin reductase system in the metabolic syndrome: towards a possible prognostic marker?
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DOI: 10.1007/s00018-018-2745-8
Abstract: Mammalian thioredoxin reductase (TrxR) is a selenoprotein with three existing isoenzymes (TrxR1, TrxR2, and TrxR3), which is found primarily intracellularly but also in extracellular fluids. The main substrate thioredoxin (Trx) is similarly found (as Trx1… read more here.
Keywords: thioredoxin reductase; system; reductase; thioredoxin ... See more keywords
New cyclometalated gold (III) complex targeting thioredoxin reductase: exploring as cytotoxic agents and mechanistic insights
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DOI: 10.1007/s10534-020-00235-3
Abstract: A new cyclometalated Au(III) complex highlighting a naphthoquinone-C^N scaffold with formula (NQ-N^C)Au III (SAd)Cl, 1 , in which NQ-N^C: 2-(5-amino-benzo[h]quinolone)-3-(3-methyl-2-butenyl)-1,4-naphthoquinone, HSAd: 1-adamantanethiol, was synthesized and characterized. The interaction of complex 1 with cysteine (CysH) was… read more here.
Keywords: thioredoxin reductase; new cyclometalated; iii complex;
Overview of structurally homologous flavoprotein oxidoreductases containing the low Mr thioredoxin reductase-like fold - A functionally diverse group.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2021.108826
Abstract: Structural studies show that enzymes have a limited number of unique folds, although structurally related enzymes have evolved to perform a large variety of functions. In this review, we have focused on enzymes containing the… read more here.
Keywords: thioredoxin reductase; like fold; containing low; trxr like ... See more keywords
Inhibition of thioredoxin reductase 1 correlates with platinum-based chemotherapeutic induced tissue injury.
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DOI: 10.1016/j.bcp.2020.113873
Abstract: Platinum-containing drugs (PtDs; e.g. cisplatin, carboplatin, and oxaliplatin) have been widely used as anticancer reagents against various cancers. However, treatment with these drugs results in undesirable adverse effects with unknown mechanisms. Herein, we found a… read more here.
Keywords: thioredoxin reductase; tissue injury; injury; cisplatin ... See more keywords
Repurposing of auranofin: Thioredoxin reductase remains a primary target of the drug.
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DOI: 10.1016/j.biochi.2019.03.015
Abstract: Auranofin is a gold (I)-containing compound used for the treatment of rheumatic arthritis. Auranofin has anticancer activity in animal models and is approved for clinical trials for lung and ovarian carcinomas. Both the cytosolic and… read more here.
Keywords: thioredoxin reductase; inhibitor; proteasome; activity ... See more keywords
Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent.
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DOI: 10.1016/j.ejmech.2017.09.027
Abstract: Mammalian thioredoxin reductase (TrxR) enzymes play a crucial role in regulating multiple redox-based signaling pathways and have attracted increasing attention as promising anticancer drug targets. We report here the synthesis of a panel of naphthazarin… read more here.
Keywords: thioredoxin reductase; synthesis; compound; naphthazarin derivatives ... See more keywords
Significance of the mitochondrial thioredoxin reductase in cancer cells: An update on role, targets and inhibitors
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DOI: 10.1016/j.freeradbiomed.2018.03.043
Abstract: ABSTRACT Thioredoxin reductase 2 (TrxR2) is a key component of the mitochondrial thioredoxin system able to transfer electrons to peroxiredoxin 3 (Prx3) in a reaction mediated by thioredoxin 2 (Trx2). In this way, both the… read more here.
Keywords: thioredoxin reductase; mitochondrial thioredoxin; thioredoxin; cancer cells ... See more keywords
Thioredoxin reductase 1 knockdown disrupts pigment synthesis in melanocytes
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DOI: 10.1016/j.freeradbiomed.2018.10.131
Abstract: Our labs have shown that levels of the antioxidant enzyme thioredoxin reductase 1 (TR1) is increased in human malignant melanomas relative to benign nevi (moles), and that TR1 knockdown affects mitochondrial metabolism in human melanomas.… read more here.
Keywords: thioredoxin reductase; reductase knockdown; tr1; knockdown disrupts ... See more keywords
The “not-so-vulnerable” β-cell
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.10.219
Abstract: Oxidative stress, mediated by reactive oxygen species (ROS) like superoxide and H2O2, is thought to promote pancreatic β-cell dysfunction and contribute to type 1 and type 2 diabetes. When blood glucose is chronically elevated, it… read more here.
Keywords: thioredoxin reductase; vulnerable cell; biology; h2o2 ... See more keywords