The Unprecedented Versatility of the Plant‎ Thioredoxin System.
Sign Up to like & getrecommendations! Published in 2017 at "Trends in plant science"
DOI: 10.1016/j.tplants.2016.12.008
Abstract: Thioredoxins are ubiquitous enzymes catalyzing reversible disulfide-bond formation to regulate structure and function of many proteins in diverse organisms. In recent years, reverse genetics and biochemical approaches were used to resolve the functions, specificities, and… read more here.
Keywords: thioredoxin; thioredoxin system; versatility plant; unprecedented versatility ... See more keywords
Novel strategies for targeting the thioredoxin system for cancer therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Expert opinion on drug discovery"
DOI: 10.1080/17460441.2022.2045270
Abstract: INTRODUCTION : The thioredoxin system is increasingly recognized as an important executor for maintaining cell redox homeostasis and regulating multiple cell signaling pathways. Targeting this system for cancer treatment has therefore attracted much attention. AREAS… read more here.
Keywords: system cancer; system; thioredoxin system; targeting thioredoxin ... See more keywords
Pathogenic role of the SP/ NK1R system in GBM cells through inhibiting the thioredoxin system
Sign Up to like & getrecommendations! Published in 2021 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2021.52902.11945
Abstract: Objective(s): Glioblastoma multiforme (GBM), a highly aggressive Grade IV brain tumor, is a significant public health issue due to its poor prognosis and incurability. Neuropeptide substance P (SP) plays a critical role in GBM tumor… read more here.
Keywords: role; thioredoxin system; system; gbm cells ... See more keywords
Repurposing Auranofin, Ebselen, and PX-12 as Antimicrobial Agents Targeting the Thioredoxin System
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2018.00336
Abstract: As microbial resistance to drugs continues to rise at an alarming rate, finding new ways to combat pathogens is an issue of utmost importance. Development of novel and specific antimicrobial drugs is a time-consuming and… read more here.
Keywords: antimicrobial agents; thioredoxin system; auranofin ebselen; thioredoxin ... See more keywords
The Role of the Thioredoxin System in Brain Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11112161
Abstract: The thioredoxin system, consisting of thioredoxin (Trx), thioredoxin reductase (TrxR), and NADPH, plays a fundamental role in the control of antioxidant defenses, cell proliferation, redox states, and apoptosis. Aberrations in the Trx system may lead… read more here.
Keywords: system; thioredoxin system; role; brain ... See more keywords