Synthesis, characterization and molecular docking studies of thiouracil derivatives as potent thymidylate synthase inhibitors and potential anticancer agents
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DOI: 10.1007/s11030-017-9776-1
Abstract: Thymidylate synthase (TS), one of folate-dependent enzymes, is a key and well-recognized target for anticancer agents. In this study, a series of 6-aryl-5-cyano thiouracil derivatives were designed and synthesized in accordance with essential pharmacophoric features… read more here.
Keywords: anti proliferative; anticancer agents; thymidylate synthase; thiouracil derivatives ... See more keywords