Masking thiol reactivity with thioamide, thiourea, and thiocarbamate-based MBPs.
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DOI: 10.1039/d2cc06596g
Abstract: Thioamides, thioureas, and thiocarbamates are introduced as stable, sulfur-based metal-binding pharmacophores (MBPs) for use in metalloenzyme fragment-based drug discovery (mFBDD). MBP reactivity, bioactivity, and structural studies show that these molecules can act as ligands for… read more here.
Keywords: thiourea thiocarbamate; thiol reactivity; thioamide thiourea; masking thiol ... See more keywords