Prebiotic phosphorylation of 2-thiouridine provides either nucleotides or DNA building blocks via photoreduction
Sign Up to like & getrecommendations! Published in 2019 at "Nature Chemistry"
DOI: 10.1038/s41557-019-0225-x
Abstract: AbstractBreakthroughs in the study of the origin of life have demonstrated how some of the building blocks essential to biology could have been formed under various primordial scenarios, and could therefore have contributed to the… read more here.
Keywords: thiouridine; phosphorylation thiouridine; building blocks; dna ... See more keywords
Selective and sensitive fluorescence "turn-on" detection of 4-thiouridine in nucleic acids via oxidative amination.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc06312a
Abstract: A fluorescence "turn-on" method for digestion-free analysis of 4-thiouridine (s4U) in nucleic acids was developed in this work based on the oxidative amination of s4U by fluoresceinamine (FAM-NH2) and periodate (IO4-). It was 125-fold more… read more here.
Keywords: thiouridine; oxidative amination; fluorescence turn; nucleic acids ... See more keywords