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Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11050948
Abstract: The rate-determining role of tyrosinase makes it a critical component in the mechanism that is responsible for melanogenesis. Thirteen (Z)-5-(substituted benzylidene)-3-phenyl-2-thioxothiazolidin-4-one ((Z)-BPTT) analogs were designed based on the structural features of two potent tyrosinase inhibitors,…
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Keywords:
phenyl thioxothiazolidin;
benzylidene phenyl;
substituted benzylidene;
tyrosinase ... See more keywords
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Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11101918
Abstract: Many compounds containing the β-phenyl-α,β-unsaturated carbonyl (PUSC) scaffold, including cinnamamide derivatives, have been shown to inhibit tyrosinase potently in vitro and in vivo. Structural changes to cinnamamide derivatives were produced by adding a dithionate functional…
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Keywords:
benzylidene cyclohexyl;
cyclohexyl thioxothiazolidin;
substituted benzylidene;
tyrosinase ... See more keywords
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Published in 2021 at "Molecules"
DOI: 10.3390/molecules26164963
Abstract: To confirm that the β-phenyl-α,β-unsaturated thiocarbonyl (PUSTC) scaffold, similar to the β-phenyl-α,β-unsaturated carbonyl (PUSC) scaffold, acts as a core inhibitory structure for tyrosinase, twelve (Z)-5-(substituted benzylidene)-4-thioxothiazolidin-2-one ((Z)-BTTZ) derivatives were designed and synthesized. Seven of the…
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Keywords:
thioxothiazolidin one;
substituted benzylidene;
benzylidene thioxothiazolidin;
tyrosinase ... See more keywords