LAUSR

Thiyl Radical-Based Charge Tagging Enables Sterol Quantitation via Mass Spectrometry.

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0 Published in 2017 at "Analytical chemistry"

DOI: 10.1021/acs.analchem.7b04080

Abstract: Inspired by the high reactivity and specificity of thiyl radicals toward alkenes, we have developed a new charge derivatization method to enable fast and quantitative analysis of sterols via electrospray ionization-mass spectrometry (ESI-MS). Thioglycolic acid… read more here.

Keywords: mass spectrometry; thiyl radical; charge tagging; charge ... See more keywords

Photoactive Metal-Organic Frameworks for the Selective Synthesis of Thioethers: Coupled with Phosphine to Modulate Thiyl Radical Generation.

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0 Published in 2021 at "Inorganic chemistry"

DOI: 10.1021/acs.inorgchem.1c00642

Abstract: Metal-organic framework (MOF) materials are intriguing photocatalysts to trigger radical-mediated chemical transformations. We report herein the synthesis and characterization of a series of isomorphic MOFs which show a novel structure, wide visible-light absorption, high chemical… read more here.

Keywords: thiyl; thiyl radical; metal organic; generation ... See more keywords

Disulfide-Bridged Peptides That Mediate Enantioselective Cycloadditions through Thiyl Radical Catalysis.

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0 Published in 2018 at "Organic letters"

DOI: 10.1021/acs.orglett.8b00364

Abstract: An enantioselective vinylcyclopropane ring-opening/cycloaddition cascade is described. The active thiyl radical catalysts are generated in situ via UV light-promoted homolysis of cystine-based dimers. Amide-functionalization of the peptide at the 4-proline position is essential for effective… read more here.

Keywords: mediate enantioselective; thiyl radical; enantioselective cycloadditions; disulfide bridged ... See more keywords

Thiyl Radical Reactions in the Chemical Degradation of Pharmaceutical Proteins

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0 Published in 2019 at "Molecules"

DOI: 10.3390/molecules24234357

Abstract: Free radical pathways play a major role in the degradation of protein pharmaceuticals. Inspired by biochemical reactions carried out by thiyl radicals in various enzymatic processes, this review focuses on the role of thiyl radicals… read more here.

Keywords: degradation; radical reactions; degradation pharmaceutical; thiyl radical ... See more keywords