Early brainstem [18F]THK5351 uptake is linked to cortical hyperexcitability in healthy aging
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DOI: 10.1172/jci.insight.142514
Abstract: BACKGROUND Neuronal hyperexcitability characterizes the early stages of Alzheimer’s disease (AD). In animals, early misfolded tau and amyloid-β (Aβ) protein accumulation — both central to AD neuropathology — promote cortical excitability and neuronal network dysfunction.… read more here.
Keywords: 18f thk5351; cortical excitability; excitability; brainstem ... See more keywords