A study of the THP‐1 cell line as the potential biologics production platform with the emphasis on serum‐free media substitution for economic expediency
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology Journal"
DOI: 10.1002/biot.202200154
Abstract: Cell cultures are frequently preferred in the industrial production of high value‐added biopharmaceuticals on a large scale. In the production of biopharmaceuticals, the selection of the appropriate cell line, the cell culture medium, and the… read more here.
Keywords: cell; cell line; thp; serum free ... See more keywords
THP-1 reference data: proposal of an in vitro branched evolution model for cancer cell lines.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of cancer"
DOI: 10.1002/ijc.34019
Abstract: THP-1 is a representative leukemia cell line and is registered with four different numbers in JCRB and RIKEN BRC cell banks. However, differences between these four lines remain unclear. In this study, these four THP-1… read more here.
Keywords: thp; vitro branched; jcrb0112; branched evolution ... See more keywords
Consequences of incorporating thiaproline and its oxidized derivatives into collagen triple helices
Sign Up to like & getrecommendations! Published in 2023 at "Protein Science"
DOI: 10.1002/pro.4650
Abstract: (2R)‐4‐thiaproline (Thp) is an analog of proline, replacing Cγ in the pyrrolidine ring with sulfur. Its thiazolidine ring easily interconverts between endo and exo puckers due to a small energy barrier, which leads to destabilize… read more here.
Keywords: oxidized derivatives; derivatives collagen; thp; consequences incorporating ... See more keywords
The IL-1 promoter-driven luciferase reporter cell line THP-G1b can efficiently predict skin-sensitising chemicals.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of toxicology"
DOI: 10.1007/s00204-021-03022-2
Abstract: IL-1 functions as an essential pro-inflammatory mediator for the sensitisation of allergic contact dermatitis (ACD). However, studies conducted to date have typically used a limited number of haptens and examined their effects only on murine ACD… read more here.
Keywords: reporter; thp g1b; cell line; thp ... See more keywords
M2-like polarization of THP-1 monocyte-derived macrophages under chronic iron overload
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Hematology"
DOI: 10.1007/s00277-020-03916-8
Abstract: Macrophages are characterized by phenotypical and functional heterogeneity. In different microenvironments, macrophages can polarize into two types: classically activated macrophages (M1) or alternatively activated macrophages (M2). M1 macrophages are a well-known bacteriostatic macrophage, and conversely,… read more here.
Keywords: chronic iron; thp; iron overload; derived macrophages ... See more keywords
Silencing YKL-40 gene can inhibit inflammatory factor expression and affects the effect of THP-1 cells on endometrial cancer
Sign Up to like & getrecommendations! Published in 2021 at "Archives of Gynecology and Obstetrics"
DOI: 10.1007/s00404-021-06194-5
Abstract: To investigate the effect of silencing the YKL-40 gene on the expression of inflammatory factors and the effect of silencing the YKL-40 gene of THP-1 cells on endometrial cancer. We used a siRNA targeting a… read more here.
Keywords: ykl gene; thp; endometrial cancer; silencing ykl ... See more keywords
Effectiveness and tolerability of neoadjuvant pertuzumab-containing regimens for HER2-positive localized breast cancer
Sign Up to like & getrecommendations! Published in 2018 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-018-4959-8
Abstract: PurposeBased on improvement in pathologic complete response (pCR) in the NeoSphere and TRYPHAENA studies, the FDA approved neoadjuvant pertuzumab for HER2+ localized breast cancer. These studies demonstrated high pCR rates with THP (docetaxel + HP), FEC (5-fluorouracil, epirubicin,… read more here.
Keywords: cancer; neoadjuvant pertuzumab; thp; breast cancer ... See more keywords
Initial genetic dissection of serum neuroactive steroids following chronic intermittent ethanol across BXD mouse strains.
Sign Up to like & getrecommendations! Published in 2017 at "Alcohol"
DOI: 10.1016/j.alcohol.2016.07.011
Abstract: Neuroactive steroids modulate alcohol's impact on brain function and behavior. Ethanol exposure alters neuroactive steroid levels in rats, humans, and some mouse strains. We conducted an exploratory analysis of the neuroactive steroids (3α,5α)-3-hydroxypregnan-20-one (3α,5α-THP), (3α,5α)-3,21-dihydroxypregnan-20-one… read more here.
Keywords: neuroactive steroids; variation; thp; mouse strains ... See more keywords
Low-temperature thermal hydrolysis for anaerobic digestion facility in wastewater treatment plant with primary sludge fermentation
Sign Up to like & getrecommendations! Published in 2021 at "Chemical Engineering Journal"
DOI: 10.1016/j.cej.2021.130485
Abstract: Abstract Primary sludge (PS) fermentation prior to anaerobic digestion (AD) is becoming more common in wastewater treatment plants (WWTPs) for the production and utilization of volatile fatty acids-rich sludge liquor in biological nutrient removal processes.… read more here.
Keywords: thp; scheme; primary sludge; low temperature ... See more keywords
Indole-linked 1,2,3-triazole derivatives efficiently modulate COX-2 protein levels in human THP-1 monocytes by suppressing AGE-ROS-NF-kβ nexus.
Sign Up to like & getrecommendations! Published in 2022 at "Life sciences"
DOI: 10.1016/j.lfs.2021.120282
Abstract: AIMS AGEs augment inflammatory responses by activating inflammatory cascade in monocytes, and hence lead to vascular dysfunction. The current study aims to study a plausible role and mechanism of new library of indole-tethered 1,2,3-triazoles 2-13… read more here.
Keywords: cox protein; protein levels; thp monocytes; suppressing age ... See more keywords
The effect of acyl chain length and saturation on the interactions of pirarubicin with phosphatidylethanolamines in 2D model urothelial cancer cell membranes
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2020.114633
Abstract: Abstract The interactions of an anticancer drug pirarubicin (THP) with a series of phosphatidylethanolamine (PE) lipids differing in the length and unsaturation degree of acyl chains were investigated using the Langmuir technique supplemented with Brewster… read more here.
Keywords: urothelial cancer; thp; cell membranes; drug ... See more keywords