Prostate cancer cells modulate the differentiation of THP‐1 cells in response to etoposide and TLR agonists treatments
Sign Up to like & getrecommendations! Published in 2020 at "Cell Biology International"
DOI: 10.1002/cbin.11410
Abstract: The aim of this study was to determine the polarization of macrophages in the tumor microenvironment, as well as the effect of soluble factors secreted from these polarized macrophages on etoposide‐induced cancer cell apoptosis. We… read more here.
Keywords: pc3 cells; tlr agonists; cancer cells; cancer ... See more keywords
A20 restores phorbol ester‐induced differentiation of THP‐1 cells in the absence of nuclear factor‐κB activation
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26308
Abstract: A20, also referred to as tumor necrosis factor alpha (TNFα)‐induced protein 3 (TNFAIP3), is an ubiquitin‐editing enzyme whose expression is enhanced by NF‐κB activation, and plays an important role in silencing NF‐κB activity. Another well‐known… read more here.
Keywords: expression; differentiation; a20; activity ... See more keywords
Silencing YKL-40 gene can inhibit inflammatory factor expression and affects the effect of THP-1 cells on endometrial cancer
Sign Up to like & getrecommendations! Published in 2021 at "Archives of Gynecology and Obstetrics"
DOI: 10.1007/s00404-021-06194-5
Abstract: To investigate the effect of silencing the YKL-40 gene on the expression of inflammatory factors and the effect of silencing the YKL-40 gene of THP-1 cells on endometrial cancer. We used a siRNA targeting a… read more here.
Keywords: ykl gene; thp; endometrial cancer; silencing ykl ... See more keywords
Development of an In Vitro Model of Inflammatory Cytokine Influences on Intervertebral Disk Cells in 3D Cell Culture Using Activated Macrophage-Like THP-1 Cells
Sign Up to like & getrecommendations! Published in 2018 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-018-4304-6
Abstract: We developed a new model for evaluation of the influence of proinflammatory cytokines on intervertebral disc cells in a 3D culture based on co-culturing of these cells with activated macrophage-like THP-1 cells. The levels of… read more here.
Keywords: macrophage like; model; activated macrophage; culture ... See more keywords
All-trans retinoic acid increases NF-κB activity in PMA-stimulated THP-1 cells upon unmethylated CpG challenge by enhancing cell surface TLR9 expression
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-020-03817-4
Abstract: An active metabolite of vitamin A, all-trans retinoic acid (ATRA), is known to exert immunomodulatory functions. This study investigates the possible immune potentiating effect of ATRA on NF-κB activity in human monocytic THP-1 cells after… read more here.
Keywords: expression; cell surface; activity; thp cells ... See more keywords
Inflammation Induced by Candida parapsilosis in THP-1 Cells and Human Peripheral Blood Mononuclear Cells (PBMCs)
Sign Up to like & getrecommendations! Published in 2017 at "Mycopathologia"
DOI: 10.1007/s11046-017-0187-8
Abstract: Candida parapsilosis is one of the most prevalent Candida species; however, the inflammation response induced by C. parapsilosis and related mechanism received few studies. In this study, we analyzed the pro-inflammatory cytokine responses evoked by… read more here.
Keywords: human peripheral; candida parapsilosis; parapsilosis; peripheral blood ... See more keywords
Immunomodulatory Effects of Monascus spp.-Fermented Sacccharina japonica Extracts on the Cytokine Gene Expression of THP-1 Cells
Sign Up to like & getrecommendations! Published in 2018 at "Applied Biochemistry and Biotechnology"
DOI: 10.1007/s12010-018-02930-x
Abstract: AbstractThe immunomodulatory effects of Monascus-fermented Saccharina japonica extract on anti- and pro-inflammatory cytokines gene expression of THP-1 cells were evaluated. Extracts of fermented samples showed higher phenolic, flavonoid, protein, and reducing sugar contents than unfermented… read more here.
Keywords: expression thp; cells treated; gene expression; expression ... See more keywords
Shape and surface properties of titanate nanomaterials influence differential cellular uptake behavior and biological responses in THP-1 cells
Sign Up to like & getrecommendations! Published in 2017 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2016.12.014
Abstract: We investigated cellular uptake behavior and biological responses of spherical and fibrous titanate nanomaterials in human monocyte THP-1 cells. Two titanate nanofibers (TiNFs), namely TF-1 and TF-2, were synthesized from anatase TiO2 nanoparticles (TNPs) via… read more here.
Keywords: titanate nanomaterials; surface; uptake behavior; cellular uptake ... See more keywords
LRP1 receptor‐mediated immunosuppression of &agr;‐MMC on monocytes
Sign Up to like & getrecommendations! Published in 2019 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2019.01.036
Abstract: Abstract Alpha‐MMC is a type I ribosome‐inactivating protein purified from bitter gourd that has strong anti‐tumour and antiviral activity. Alpha‐MMC also has immunosuppressive effects, but the mechanism of these immunosuppressive effects remains unclear. It is… read more here.
Keywords: agr mmc; lrp1 receptor; mmc; thp cells ... See more keywords
Inhibition of inflammatory-molecule synthesis in THP-1 cells stimulated with phorbol 12-myristate 13-acetate by brefelamide derivatives.
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.105831
Abstract: Plasma osteopontin (OPN) levels are elevated in tuberculosis patients and may involve granuloma formation. New inhibitors using brefelamide, an aromatic amide isolated from Dictyostelium cellular slime molds that may inhibit OPN transcription in A549 cells… read more here.
Keywords: myristate acetate; phorbol myristate; synthesis; thp cells ... See more keywords
The role of CECR1 in the immune-modulatory effects of butyrate and correlation between ADA2 and M1/M2 chemokines in tuberculous pleural effusion.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.107635
Abstract: OBJECTIVES The Cat Eye Syndrome Critical Region, Candidate 1 (CECR1) gene encoding adenosine deaminase 2 (ADA2) is mainly expressed by macrophages. Given the immunomodulatory functions of butyrate, we examined the effect of butyrate on CECR1… read more here.
Keywords: butyrate; correlation; ada2; cecr1 ... See more keywords