The IL-1 promoter-driven luciferase reporter cell line THP-G1b can efficiently predict skin-sensitising chemicals.
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DOI: 10.1007/s00204-021-03022-2
Abstract: IL-1 functions as an essential pro-inflammatory mediator for the sensitisation of allergic contact dermatitis (ACD). However, studies conducted to date have typically used a limited number of haptens and examined their effects only on murine ACD… read more here.
Keywords: reporter; thp g1b; cell line; thp ... See more keywords