MicroRNA‐181a regulates the activation of the NLRP3 inflammatory pathway by targeting MEK1 in THP‐1 macrophages stimulated by ox‐LDL
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28637
Abstract: Atherosclerosis (AS) is a chronic inflammatory disease that is characterized by the deposition of lipids in the vascular wall and the formation of foam cells. Macrophages play a critical role in the development of this… read more here.
Keywords: related proteins; pathway; expression; thp macrophages ... See more keywords
The potential immunotoxicity of emamectin benzoate on the human THP‐1 macrophages
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23681
Abstract: Emamectin benzoate (EMB) as one of the typical biological pesticides has a wide range of applications in agriculture. However, the immune toxic effects of EMB in human received limited attention. In our study, THP‐1 macrophage… read more here.
Keywords: thp macrophages; immunotoxicity; emamectin benzoate; potential immunotoxicity ... See more keywords
Aspergillus fumigatus-Stimulated Human Corneal Epithelial Cells Induce Pyroptosis of THP-1 Macrophages by Secreting TSLP
Sign Up to like & getrecommendations! Published in 2020 at "Inflammation"
DOI: 10.1007/s10753-020-01367-x
Abstract: Fungal keratitis (FK) is a keratopathy caused by pathogenic fungal infection. The aim of this work is to explore the role of thymic stromal lymphopoietin (TSLP) in FK. Human corneal epithelial cells (HCECs) were treated… read more here.
Keywords: aspergillus fumigatus; tslp; treatment; thp macrophages ... See more keywords
LIGHT is increased in patients with coronary disease and regulates inflammatory response and lipid metabolism in oxLDL-induced THP-1 macrophages.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.06.110
Abstract: Inflammation is critical for the progression of hyperlipidemia. Although the exact mechanism through which inflammation affects hyperlipidemia is not very clear, evidence suggests that the tumor necrosis factor superfamily member 14 (TNFSF14/LIGHT)LIGHT might regulate lipid… read more here.
Keywords: coronary disease; thp macrophages; induced thp; oxldl induced ... See more keywords
The reactive oxygen species as pathogenic factors of fragmented microplastics to macrophages.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental pollution"
DOI: 10.1016/j.envpol.2021.117006
Abstract: The presence of microplastics in the various food web raised concerns on human health, but little is known about the target cells and mechanism of toxicity of microplastics. In this study, we evaluated the toxicity… read more here.
Keywords: reactive oxygen; oxygen species; toxicity; ros generation ... See more keywords
microRNA-212 promotes lipid accumulation and attenuates cholesterol efflux in THP-1 human macrophages by targeting SIRT1.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2017.11.058
Abstract: Macrophage foam cell formation is a key initiating event in the pathogenesis of atherosclerosis. This work was conducted to determine the role of microRNA (miR)-212 in the transformation of foam cells from macrophages. We examined… read more here.
Keywords: sirt1; lipid accumulation; mir 212; thp macrophages ... See more keywords
In vitro evaluation of the involvement of Nrf2 in maslinic acid-mediated anti-inflammatory effects in atheroma pathogenesis.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119658
Abstract: AIMS Maslinic acid (MA) is a naturally occurring pentacyclic triterpene known to exert cardioprotective effects. This study aims to investigate the involvement of nuclear factor erythroid 2-related factor 2 (Nrf2) for MA-mediated anti-inflammatory effects in… read more here.
Keywords: anti inflammatory; expression; thp macrophages; inflammatory effects ... See more keywords
Calcium sensing receptor activation in THP-1 macrophages triggers NLRP3 inflammasome and human preadipose cell inflammation
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2019.110654
Abstract: Excess adipose tissue (AT) associates with inflammation and obesity-related diseases. We studied whether calcium-sensing receptor (CaSR)-mediated NLRP3 inflammasome activation in THP-1 macrophages elevates inflammation in LS14 preadipocytes, modeling deleterious AT cell crosstalk. THP-1 macrophages exposed… read more here.
Keywords: inflammation; thp macrophages; activation; nlrp3 inflammasome ... See more keywords
Oxidized LDL triggers changes in oxidative stress and inflammatory biomarkers in human macrophages
Sign Up to like & getrecommendations! Published in 2018 at "Redox Biology"
DOI: 10.1016/j.redox.2017.11.017
Abstract: Oxidized low-density lipoprotein (oxLDL) is a well-recognized proatherogenic particle that functions in atherosclerosis. In this study, we established conditions to generate human oxLDL, characterized according to the grade of lipid and protein oxidation, particle size… read more here.
Keywords: oxidized ldl; isop; ldl triggers; thp macrophages ... See more keywords
Induction of lipid droplets in THP-1 macrophages by multi-walled carbon nanotubes in a diameter-dependent manner: a transcriptomic study.
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2020.07.007
Abstract: Exposure to multi-walled carbon nanotubes (MWCNTs) might induce lipid droplet (LD) biogenesis, but the roles of physicochemical properties of MWCNTs, as well as the mechanisms, remain poorly understood. In this study, we investigated lipid laden… read more here.
Keywords: walled carbon; carbon nanotubes; study; diameter dependent ... See more keywords
Dysfunction of cholesterol sensor SCAP promotes inflammation activation in THP‐1 macrophages
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2018.03.032
Abstract: ABSTRACT Crosstalk occurs between dyslipidemia and chronic inflammation, which are both precipitants of atherosclerosis. Sterol regulatory element binding proteins cleavage‐activating protein (SCAP) plays a key role in regulating cholesterol homeostasis. The present study investigated the… read more here.
Keywords: dysfunction; cholesterol; scap; expression ... See more keywords