Thrombopoietin mutation in congenital amegakaryocytic thrombocytopenia treatable with romiplostim
Sign Up to like & getrecommendations! Published in 2018 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.201708168
Abstract: Congenital amegakaryocytic thrombocytopenia (CAMT) is an inherited disorder characterized at birth by thrombocytopenia with reduced megakaryocytes, which evolves into generalized bone marrow aplasia during childhood. Although CAMT is genetically heterogeneous, mutations of MPL, the gene… read more here.
Keywords: thrombopoietin; thrombocytopenia; congenital amegakaryocytic; amegakaryocytic thrombocytopenia ... See more keywords
Thrombopoietin from hepatocytes promotes hematopoietic stem cell regeneration after myeloablation
Sign Up to like & getrecommendations! Published in 2021 at "eLife"
DOI: 10.7554/elife.69894
Abstract: The bone marrow niche plays critical roles in hematopoietic recovery and hematopoietic stem cell (HSC) regeneration after myeloablative stress. However, it is not clear whether systemic factors beyond the local niche are required for these… read more here.
Keywords: bone marrow; stem cell; thpo; myeloablation ... See more keywords