Mechanisms for DNA-damaging agent-induced inactivation of ErbB2 and ErbB3 via the ERK and p38 signaling pathways.
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DOI: 10.3892/ol.2017.7532
Abstract: Cisplatin (CDDP) and doxorubicin (DOX) are chemotherapeutic drugs that trigger apoptosis by inducing DNA-damage. A previous study using breast cancer cells demonstrated the negative feedback modulation of the epidermal growth factor receptor (EGFR) and receptor… read more here.
Keywords: erk p38; erbb2; thr 677; erbb2 erbb3 ... See more keywords