Assessment of children in the autistic spectrum disorder that carry the Thr92Ala-DIO2 polymorphism
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DOI: 10.1007/s40618-020-01497-x
Abstract: A polymorphism in the type 2 deiodinase (Thr92Ala-DIO2) gene has been associated with behavioral and cognitive dysfunction as well as neurodegeneration and oxidative stress in the central nervous system. To test whether the minor allele… read more here.
Keywords: thr92ala dio2; dio2 polymorphism; minor allele; spectrum disorder ... See more keywords
Type 2 Deiodinase Thr92Ala Polymorphism Is Not Associated with Cognitive Impairment in Older Adults: A Cross-Sectional Study
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DOI: 10.3390/metabo12050375
Abstract: Background: Type 2 Deiodinase (DIO2) converts thyroxine (T4) into the active hormone triiodothyronine (T3). Thr92Ala DIO2 polymorphism has been associated with reduced conversion of T4 into T3 and central nervous system hypothyroidism. However, how Thr92Ala… read more here.
Keywords: dio2 polymorphism; polymorphism; thr92ala dio2; older adults ... See more keywords
Age Worsens the Cognitive Phenotype in Mice Carrying the Thr92Ala-DIO2 Polymorphism
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DOI: 10.3390/metabo12070629
Abstract: The Thr92Ala-Dio2 polymorphism has been associated with reduced cognition in 2-month-old male mice and increased risk for cognitive impairment and Alzheimer’s disease in African Americans. This has been attributed to reduced thyroid hormone (TH) signaling… read more here.
Keywords: dio2 polymorphism; phenotype; thr92ala dio2; dio2 ... See more keywords