A Catalytic Three‐Component Aminofluorination of Unactivated Alkenes with Electron‐Rich Amino Sources
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DOI: 10.1002/advs.202305006
Abstract: We present herein a copper‐catalyzed three‐component aminofluorination of unactivated alkenes with N‐bromodialkylamines and readily available nucleophilic fluoride under the assistance of a bidentate auxiliary. This protocol exhibits excellent functional group tolerance toward a wide range… read more here.
Keywords: unactivated alkenes; component aminofluorination; aminofluorination unactivated; three component ... See more keywords
Three‐Component COFs with D−π−A Units and Side‐Chain‐Enhanced Mass Transfer Enable Efficient Sacrificial‐Agent‐Free H2O2 Photosynthesis
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DOI: 10.1002/aenm.202503108
Abstract: Photocatalytic oxygen reduction reactions (ORR) and water oxidation reactions (WOR) based on covalent organic frameworks (COFs) represent the most promising green approach for producing H2O2. However, the enhancement of COFs' photocatalytic efficiency is hindered by… read more here.
Keywords: units side; cofs units; component cofs; three component ... See more keywords
Synthesis of Iodine-Substituted Quinolines, Quinolinium Salts, and Isoquinolinium Salts via a Three-Component Tandem Reaction of Aryl Azides, Propargylic Alcohols, and Iodine
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DOI: 10.1002/ajoc.201600503
Abstract: An efficient three component tandem reaction of aryl azides, propargylic alcohols and iodine has been developed. The products of the reaction hinge on the type of the propargylic alcohols: for tertiary alcohols the reaction proceeded… read more here.
Keywords: aryl azides; three component; propargylic alcohols; reaction ... See more keywords
Catalyst‐Free Three‐Component Synthesis of α‐Amino Phosphonates
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DOI: 10.1002/ajoc.202300572
Abstract: An efficient and environmentally friendly method for the synthesis of α‐amino phosphonates has been reported using the one‐pot, three‐component reaction of various substituted anilines and benzaldehydes with diethyl phosphite in acetonitrile at 100°C. The advantages… read more here.
Keywords: three component; synthesis amino; amino phosphonates; catalyst free ... See more keywords
Three‐Component Aminoalkylations Yielding Dihydronaphthoxazine‐Based Sirtuin Inhibitors: Scaffold Modification and Exploration of Space for Polar Side‐Chains
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DOI: 10.1002/ardp.201700097
Abstract: Nonpolar derivatives of heterocyclic aromatic screening hits like the non‐selective sirtuin inhibitor splitomicin tend to be poorly soluble in biological fluids. Unlike sp3‐rich natural products, flat aromatic compounds are prone to stacking and often difficult… read more here.
Keywords: based sirtuin; aminoalkylations yielding; dihydronaphthoxazine based; three component ... See more keywords
Photoinduced Copper‐Catalyzed Three‐Component Radical Carboamination of Styrene Derivatives
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DOI: 10.1002/cctc.202401234
Abstract: The catalytic three‐component radical carboamination of alkenes has recently emerged as an alternative and robust platform for the rapid construction of diverse and valuable amines. Despite great advances in this field, new methods that enable… read more here.
Keywords: catalyzed three; radical carboamination; three component; copper catalyzed ... See more keywords
Three-Component Povarov Reaction with Alcohols as Alkene Precursors: Efficient Access to 2-Arylquinolines
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DOI: 10.1002/ejoc.201601343
Abstract: An atom-economic and efficient approach to the synthesis of 2-arylquinolines has been developed. The protocol involves an iron-catalysed cascade N-alkylation/aerobic oxidation/Povarov reaction, and the desired quinolines were prepared in moderate to excellent yields from readily… read more here.
Keywords: component povarov; povarov; etoh nproh; three component ... See more keywords
Efficient Diastereoselective Three-Component Synthesis of Pipecolic Amides
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DOI: 10.1002/ejoc.201900399
Abstract: An efficient Ugi-type three-component reaction (U-3CR) for the synthesis of pipecolic amides is reported. The U-3CR between electronically diverse isocyanides, carboxylic acids and 4-substituted Δ1-piperideines proceeds in a highly diastereoselective fashion. The Δ1-piperideines are obtained… read more here.
Keywords: pipecolic amides; synthesis; three component; efficient diastereoselective ... See more keywords
Photocatalytic Three‐Component α‐Trifluoroalkyl‐β‐heteroarylation of Unactivated Alkenes with Trifluoroacetates
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DOI: 10.1002/ejoc.202400326
Abstract: We herein disclose a direct and practical photocatalytic three‐component α‐trifluoroalkyl‐β‐heteroarylation of various unactivated alkenes with trifluoroacetates and quinoxalin‐2(1H)‐ones. The reaction takes place via a photoinduced LMCT process, allowing efficient synthesis of a variety of 3‐fluoroalkylated… read more here.
Keywords: component trifluoroalkyl; unactivated alkenes; photocatalytic three; three component ... See more keywords
Three‐Component Synthesis of Fluorescent 1,4‐Benzothiazin‐2‐ones through Thiol‐Free Iodine‐Catalyzed Cyclization
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DOI: 10.1002/ejoc.202400715
Abstract: A convergent synthesis of 2H‐benzo[b][1,4]thiazin‐2‐one was achieved via iodine‐catalyzed three‐component reaction. This strategy involves the formation of two new C–S bonds and a C–N bond from the readily available precursors ‐ aryl methyl ketones, p‐anisidine, and… read more here.
Keywords: three component; iodine catalyzed; synthesis fluorescent; component synthesis ... See more keywords
Chemoselective Synthesis of Tetrahydropyrimidines and Dihydropyrrolidones through Three‐Component Reaction of Amines, 1,3,5‐Triazinanes, and Alkyne Esters
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DOI: 10.1002/ejoc.202401400
Abstract: A three‐component reaction of amines, 1,3,5‐triazinanes, and alkyne esters for the construction of tetrahydropyrimidines and dihydropyrrolidones derivatives was reported. Shifting the substituent group of 1,3,5‐triazinanes led to the chemoselective synthesis. As three‐atom synthons, aryl substituted… read more here.
Keywords: amines triazinanes; component reaction; three component; synthesis ... See more keywords