Synthesis of Iodine-Substituted Quinolines, Quinolinium Salts, and Isoquinolinium Salts via a Three-Component Tandem Reaction of Aryl Azides, Propargylic Alcohols, and Iodine
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DOI: 10.1002/ajoc.201600503
Abstract: An efficient three component tandem reaction of aryl azides, propargylic alcohols and iodine has been developed. The products of the reaction hinge on the type of the propargylic alcohols: for tertiary alcohols the reaction proceeded… read more here.
Keywords: aryl azides; three component; propargylic alcohols; reaction ... See more keywords
Three‐Component Aminoalkylations Yielding Dihydronaphthoxazine‐Based Sirtuin Inhibitors: Scaffold Modification and Exploration of Space for Polar Side‐Chains
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DOI: 10.1002/ardp.201700097
Abstract: Nonpolar derivatives of heterocyclic aromatic screening hits like the non‐selective sirtuin inhibitor splitomicin tend to be poorly soluble in biological fluids. Unlike sp3‐rich natural products, flat aromatic compounds are prone to stacking and often difficult… read more here.
Keywords: based sirtuin; aminoalkylations yielding; dihydronaphthoxazine based; three component ... See more keywords
Three-Component Povarov Reaction with Alcohols as Alkene Precursors: Efficient Access to 2-Arylquinolines
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DOI: 10.1002/ejoc.201601343
Abstract: An atom-economic and efficient approach to the synthesis of 2-arylquinolines has been developed. The protocol involves an iron-catalysed cascade N-alkylation/aerobic oxidation/Povarov reaction, and the desired quinolines were prepared in moderate to excellent yields from readily… read more here.
Keywords: component povarov; povarov; etoh nproh; three component ... See more keywords
Efficient Diastereoselective Three-Component Synthesis of Pipecolic Amides
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DOI: 10.1002/ejoc.201900399
Abstract: An efficient Ugi-type three-component reaction (U-3CR) for the synthesis of pipecolic amides is reported. The U-3CR between electronically diverse isocyanides, carboxylic acids and 4-substituted Δ1-piperideines proceeds in a highly diastereoselective fashion. The Δ1-piperideines are obtained… read more here.
Keywords: pipecolic amides; synthesis; three component; efficient diastereoselective ... See more keywords
Microwave-assisted Three-component Reactions for Regioselective Synthesis of Functionalized Benzo[e]indoles
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DOI: 10.1002/jhet.2962
Abstract: Microwave-assisted three-component reactions of arylglyoxals with cyclic 1,3-dicarbonyl compounds and naphthalen-2-amine have been established, by which a series of new functionalized benzo[e]indoles with good yields were synthesized. The reaction was easily conducted in HOAc, enabling… read more here.
Keywords: assisted three; microwave assisted; three component; benzo indoles ... See more keywords
New Azacycles by One‐Pot Three‐Component Hantzsch‐Like Synthesis of Tetra(hexa)azacyclopenta[a]anthracenes, Tetraazaindeno[5,4‐b]fluorenes, and Oxatetraazacyclopenta[m]tetraphenes
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DOI: 10.1002/open.202300009
Abstract: Abstract New Azacycles by One‐Pot Three‐Component Hantzsch‐Like Synthesis of Tetra(hexa)azacyclopenta[a]anthracenes, Tetraazaindeno[5,4‐b]fluorenes, and Oxatetraazacyclopenta[m]tetraphenes (H. Butenschön, I. A. Abdelhamid et al.) #OpenAccess Multicomponent reactions (MCRs) are envisaged as an entry point for the synthesis of heterocyclic compounds… read more here.
Keywords: hexa azacyclopenta; azacyclopenta anthracenes; tetra hexa; tetraazaindeno fluorenes ... See more keywords
HiMoP: A three-component architecture to create more human-acceptable social-assistive robots
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DOI: 10.1007/s10339-017-0850-5
Abstract: Generation of autonomous behavior for robots is a general unsolved problem. Users perceive robots as repetitive tools that do not respond to dynamic situations. This research deals with the generation of natural behaviors in assistive… read more here.
Keywords: himop three; create human; architecture create; three component ... See more keywords
Nanostructured Zirconium Pyrophosphate Catalyzed Diastereoselective Synthesis of β-Amino Ketones via One-Pot Three-Component Mannich Reaction
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DOI: 10.1007/s10562-017-2264-5
Abstract: In this study, ZrP2O7 catalytic nanomaterials were prepared by co-precipitation and polyvinylpyrrolidone assisted methods. These nanomaterials were structurally characterized by XRD, N2 adsorption/desorption, TGA, SEM and TEM microscopy techniques. This study investigated the application of… read more here.
Keywords: mannich reaction; amino; three component; one pot ... See more keywords
One-pot three-component synthesis of a series of 4-aroyl-1,6-diaryl-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitriles in the presence of aluminum oxide as a nanocatalyst
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DOI: 10.1007/s10593-018-2229-7
Abstract: One-pot three-component reaction of arylglyoxals, 3-aryl-3-oxopropanenitriles, and 5-amino-1-aryl-3-methylpyrazoles using various solvent systems and different catalysts under reflux conditions afforded the corresponding 4-aroyl-1,6-diaryl-3-methyl-1H-pyrazolo[3,4-b]- pyridine-5-carbonitrile derivatives. The best yields (70–91%) were obtained using Al2O3 as a nanocatalyst… read more here.
Keywords: aroyl diaryl; diaryl methyl; three component; one pot ... See more keywords
One-Pot Three-Component Synthesis of Polysubstituted Tetrahydroindoles
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DOI: 10.1007/s10593-019-02600-8
Abstract: A series of novel fused pyrrole derivatives was synthesized by one-pot three-component reaction of β-enaminoketones, derived from cyclohexane-1,3-dione or dimedone, arylglyoxal hydrates, and 1,3-dimethylbarbituric acid in EtOH. read more here.
Keywords: pot three; three component; component synthesis; one pot ... See more keywords
Localized Patterns in a Three-Component FitzHugh–Nagumo Model Revisited Via an Action Functional
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DOI: 10.1007/s10884-016-9557-z
Abstract: In this manuscript, we combine geometrical singular perturbation techniques and an action functional to revisit—and further study—the existence and stability of stationary localized structures in a singularly perturbed three-component FitzHugh–Nagumo model. In particular, the action… read more here.
Keywords: nagumo model; fitzhugh nagumo; three component; action functional ... See more keywords