Articles with "three hit" as a keyword



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Construct and face validity of a new model for the three-hit theory of depression using PACAP mutant mice on CD1 background

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Published in 2017 at "Neuroscience"

DOI: 10.1016/j.neuroscience.2017.04.019

Abstract: Major depression is a common cause of chronic disability. Despite decades of efforts, no equivocally accepted animal model is available for studying depression. We tested the validity of a new model based on the three-hit… read more here.

Keywords: depression; pacap; three hit; validity ... See more keywords
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Abstract PR01: Three-hit model of Wilms’ tumor formation reveals immunogenic transcriptional subtypes

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Published in 2020 at "Cancer Research"

DOI: 10.1158/1538-7445.pedca19-pr01

Abstract: Wilms’ tumor is the most common kidney cancer in children. Despite advances in care, children with metastatic, anaplastic, or relapsed disease still fare poorly. Recent studies have uncovered novel types of driver mutations, including in… read more here.

Keywords: wilms tumor; three hit; tumor formation; microrna processing ... See more keywords