Threonine Cavities Are Targetable Motifs That Control Alpha-Synuclein Fibril Growth.
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DOI: 10.1021/acschemneuro.2c00327
Abstract: Recent high-resolution structures of alpha-synuclein (aSyn) fibrils offer promise for rational approaches to drug discovery for Parkinson's disease and Lewy body dementia. Harnessing the first such structures, we previously used molecular dynamics and free energy… read more here.
Keywords: fibril growth; alpha synuclein; threonine cavities; threonine ... See more keywords