Illuminating the Dark: Highly Selective Inhibition of Serine/Threonine Kinase 17A with Pyrazolo[1,5-a]pyrimidine-Based Macrocycles.
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DOI: 10.1021/acs.jmedchem.2c00173
Abstract: Serine/threonine kinase 17A (death-associated protein kinase-related apoptosis-inducing protein kinase 1─DRAK1) is a part of the death-associated protein kinase (DAPK) family and belongs to the so-called dark kinome. Thus, the current state of knowledge of the… read more here.
Keywords: threonine kinase; pyrazolo pyrimidine; kinase 17a; kinase ... See more keywords
Variant rs6749447 (T > G) in the serine threonine kinase gene is associated with cardiovascular complications, the Tampere adult population cardiovascular risk study
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DOI: 10.1097/md.0000000000027566
Abstract: Abstract We have previously shown an association of STK39 (serine threonine kinase) rs6749447 (T > G) with hypertension in the Tampere adult population cardiovascular risk study in 50-year-old subjects. These 1196 subjects were followed up to the… read more here.
Keywords: threonine kinase; risk; gene; rs6749447 ... See more keywords
Serine Threonine Kinase 17A Maintains the Epithelial State in Colorectal Cancer Cells
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DOI: 10.1158/1541-7786.mcr-18-0990
Abstract: Serine threonine kinase 17A (STK17A) is a ubiquitously expressed kinase originally identified as a regulator of apoptosis; however, whether it functionally contributes to colorectal cancer has not been established. Here, we have analyzed STK17A in… read more here.
Keywords: threonine kinase; serine threonine; cancer; kinase 17a ... See more keywords
Downregulation of tyrosine threonine kinase inhibits tumor growth via G2/M arrest in human endometrioid endometrial adenocarcinoma
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DOI: 10.1177/1010428317712444
Abstract: Endometrial cancer is the most common gynecologic malignancy, about 80% of which is endometrial endometrioid carcinoma. Dysregulation of spindle assembly checkpoint plays a vital role in endometrial endometrioid carcinoma tumorigenesis and progression. The purpose of… read more here.
Keywords: endometrial endometrioid; endometrioid carcinoma; threonine kinase; tyrosine threonine ... See more keywords
Serine-Threonine Kinase Receptor Associate Protein (STRAP) Confers Stemness in Neuroblastoma
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DOI: 10.1542/peds.147.3_meetingabstract.919-a
Abstract: Background: Serine-threonine kinase receptor associated protein (STRAP) is a scaffolding protein that has been implicated in tumor growth and metastasis. The role of STRAP in neuroblastoma (NB) has not been explored. Stem cell-like cancer cells… read more here.
Keywords: threonine kinase; strap; kinase receptor; protein strap ... See more keywords
Protein Kinase Serine/Threonine Kinase 24 Positively Regulates Interleukin 17-Induced Inflammation by Promoting IKK Complex Activation
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DOI: 10.3389/fimmu.2018.00921
Abstract: Interleukin 17 (IL-17) is a key inflammatory cytokine that plays a critical role in tissue inflammation and autoimmune diseases. However, its signaling remains poorly understood. In this study, we identified serine/threonine kinase 24 (Stk24) as… read more here.
Keywords: serine threonine; kinase; inflammation; threonine kinase ... See more keywords
The Role of Microtubule Associated Serine/Threonine Kinase 3 Variants in Neurodevelopmental Diseases: Genotype-Phenotype Association
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DOI: 10.3389/fnmol.2021.775479
Abstract: Objective: To prove microtubule associated serine/threonine kinase 3 (MAST3) gene is associated with neurodevelopmental diseases (NDD) and the genotype-phenotype correlation. Methods: Trio exome sequencing (trio ES) was performed on four NDD trios. Bioinformatic analysis was… read more here.
Keywords: threonine kinase; serine threonine; genotype phenotype;
Deleterious Variation in BR Serine/Threonine Kinase 2 Classified a Subtype of Autism
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DOI: 10.3389/fnmol.2022.904935
Abstract: Recently, deleterious variants in the BR serine/threonine kinase 2 (BRSK2) gene have been reported in patients with autism spectrum disorder (ASD), suggesting that BRSK2 is a new high-confidence ASD risk gene, which presents an opportunity… read more here.
Keywords: threonine kinase; autism; brsk2b zebrafish; asd ... See more keywords
Selenoproteins Protect Against Avian Liver Necrosis by Metabolizing Peroxides and Regulating Receptor Interacting Serine Threonine Kinase 1/Receptor Interacting Serine Threonine Kinase 3/Mixed Lineage Kinase Domain-Like and Mitogen-Activated Protein Kinase Signaling
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.696256
Abstract: Liver necroptosis of chicks is induced by selenium (Se)/vitamin E (VE) deficiencies and may be associated with oxidative cell damage. To reveal the underlying mechanisms of liver necrosis, a pool of the corn–soy basal diet… read more here.
Keywords: receptor interacting; serine threonine; kinase; threonine kinase ... See more keywords
ATM Serine/Threonine Kinase and its Role in Pancreatic Risk
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DOI: 10.3390/genes11010108
Abstract: Next-generation sequencing has led to the recent discovery of several novel pancreatic cancer susceptibility genes. These genes include ataxia telangiectasia mutated (ATM), a serine/threonine kinase that is an integral component of DNA repair. Pathogenic germline… read more here.
Keywords: atm serine; threonine kinase; risk; serine threonine ... See more keywords
Role of serine/threonine kinase 33 methylation in colorectal cancer and its clinical significance
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DOI: 10.3892/ol.2017.7614
Abstract: Serine/threonine kinase 33 (STK33) is a novel protein that has been the focus of an increasing number of studies in recent years; however, the role of STK33 in tumorigenesis remains controversial. Previous studies have demonstrated… read more here.
Keywords: methylation; serine threonine; threonine kinase; role ... See more keywords