Evolutionary divergence in the conformational landscapes of tyrosine vs serine/threonine kinases
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DOI: 10.7554/elife.83368
Abstract: Inactive conformations of protein kinase catalytic domains where the DFG motif has a “DFG-out” orientation and the activation loop is folded present a druggable binding pocket that is targeted by FDA-approved “type-II inhibitors” in the… read more here.
Keywords: threonine kinases; loop; energy; activation loop ... See more keywords