Targeting the messengers: Serine/threonine protein kinases as potential targets for antimycobacterial drug development
Sign Up to like & getrecommendations! Published in 2018 at "IUBMB Life"
DOI: 10.1002/iub.1871
Abstract: The emergence of increasingly drug‐resistant Mycobacterium tuberculosis strains has become a crucial public health concern. In order to effectively treat tuberculosis, it is imperative to find newer drug targets, which are important for the in… read more here.
Keywords: serine threonine; protein kinases; drug; tuberculosis ... See more keywords
The serine/threonine protein phosphatase 2A controls autoimmunity.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical immunology"
DOI: 10.1016/j.clim.2017.07.012
Abstract: Protein phosphatase 2A (PP2A) is the first serine/threonine phosphatase recognized to contribute to human and murine lupus immunopathology. PP2A expression in SLE is controlled both epigenetically and genetically, and it is increased in patients with… read more here.
Keywords: threonine protein; serine threonine; phosphatase; protein phosphatase ... See more keywords
Deletion of serine/threonine-protein kinase pknL from Mycobacterium tuberculosis reduces the efficacy of isoniazid and ethambutol.
Sign Up to like & getrecommendations! Published in 2021 at "Tuberculosis"
DOI: 10.1016/j.tube.2021.102066
Abstract: Serine/threonine-protein kinases in Mycobacterium tuberculosis (Mtb) form a preeminent regulatory system required to establish and maintain the infection in the host. Herein, we sought to decipher the biological role of PknL with the help of… read more here.
Keywords: serine threonine; isoniazid ethambutol; tuberculosis; threonine protein ... See more keywords
Discovery of Potent and Selective Receptor-Interacting Serine/Threonine Protein Kinase 2 (RIPK2) Inhibitors for the Treatment of Inflammatory Bowel Diseases (IBDs).
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00604
Abstract: Receptor-interacting serine/threonine protein kinase 2 (RIPK2) has been demonstrated to be a promising target for treating inflammatory diseases. Herein, we describe the discovery and optimization of a series of RIPK2 inhibitors derived from an FLT3… read more here.
Keywords: protein kinase; kinase ripk2; receptor interacting; interacting serine ... See more keywords
Role of serine/threonine protein kinase STN7 in the formation of two distinct photosystem I supercomplexes in Physcomitrium patens
Sign Up to like & getrecommendations! Published in 2022 at "Plant Physiology"
DOI: 10.1093/plphys/kiac294
Abstract: Abstract Reversible thylakoid protein phosphorylation provides most flowering plants with dynamic acclimation to short-term changes in environmental light conditions. Here, through generating Serine/Threonine protein kinase 7 (STN7)-depleted mutants in the moss Physcomitrella (Physcomitrium patens), we… read more here.
Keywords: protein kinase; psi; threonine protein; serine threonine ... See more keywords
PrrA modulates Mycobacterium tuberculosis response to multiple environmental cues and is critically regulated by serine/threonine protein kinases
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Genetics"
DOI: 10.1101/2022.03.20.485039
Abstract: The ability of Mycobacterium tuberculosis (Mtb) to adapt to its surrounding environment is critical for the bacterium to successfully colonize its host. Transcriptional changes are a vital mechanism by which Mtb responds to key environmental… read more here.
Keywords: mycobacterium tuberculosis; protein kinases; mtb; threonine protein ... See more keywords
Identification of highly specific antibodies for Serine/threonine-protein kinase TBK1 for use in immunoblot, immunoprecipitation and immunofluorescence
Sign Up to like & getrecommendations! Published in 2022 at "F1000Research"
DOI: 10.12688/f1000research.124632.2
Abstract: TBK1 is a serine-threonine protein kinase that has been linked to a number of diseases including amyotrophic lateral sclerosis and frontotemporal dementia. Reproducible research on TBK1 has been hampered by the lack of well characterized… read more here.
Keywords: use immunoblot; protein kinase; threonine protein; serine threonine ... See more keywords
Serine/Threonine Protein Kinase STK16
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DOI: 10.3390/ijms20071760
Abstract: STK16 (Ser/Thr kinase 16, also known as Krct/PKL12/MPSK1/TSF-1) is a myristoylated and palmitoylated Ser/Thr protein kinase that is ubiquitously expressed and conserved among all eukaryotes. STK16 is distantly related to the other kinases and belongs… read more here.
Keywords: protein; serine threonine; stk16; protein kinase ... See more keywords
The Inhibition of Serine/Threonine Protein Phosphatase Type 5 Mediates Cantharidin Toxicity to Control Periplaneta americana (L.)
Sign Up to like & getrecommendations! Published in 2020 at "Insects"
DOI: 10.3390/insects11100682
Abstract: Simple Summary The American cockroach, Periplaneta americana (L.), is a worldwide common sanitary pest. Controlling cockroaches mainly relies on chemical insecticides. However, the irrational and extensive use of insecticides has resulted in increasing resistance in… read more here.
Keywords: serine threonine; ctd; toxicity; americana ... See more keywords