Discovery of the First Examples of Threonine Tyrosine Kinase PROTAC Degraders.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01768
Abstract: The first examples of threonine tyrosine kinase (TTK) PROTACs were designed and synthesized. Two of the most potent molecules, 8e and 8j, demonstrated strong TTK degradation in COLO-205 human colorectal cancer cells with DC50 values… read more here.
Keywords: first examples; threonine tyrosine; tyrosine kinase; examples threonine ... See more keywords
TTK (threonine tyrosine kinase) regulates the malignant behaviors of cancer cells and is regulated by microRNA-582-5p in ovarian cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Bioengineered"
DOI: 10.1080/21655979.2021.1968778
Abstract: There is growing evidence that threonine tyrosine kinase (TTK) dysregulation is linked to the progression of multiple malignancies. Nonetheless, the role of TTK in ovarian cancer (OC) remains unclear. The GEO2R method was employed to… read more here.
Keywords: threonine tyrosine; ttk; mir 582; expression ... See more keywords
Knockdown of Serine Threonine Tyrosine Kinase 1 (STYK1) Inhibits the Migration and Tumorigenesis in Glioma Cells
Sign Up to like & getrecommendations! Published in 2017 at "Oncology Research"
DOI: 10.3727/096504016x14772424117423
Abstract: Pediatric glioma is a devastating brain tumor. Serine threonine tyrosine kinase 1 (STYK1) is a member of the protein tyrosine kinase family and plays a significant role in the formation of several malignant tumors. However,… read more here.
Keywords: serine threonine; glioma; threonine tyrosine; styk1 ... See more keywords