Thrombosis‐Responsive Thrombolytic Coating Based on Thrombin‐Degradable Tissue Plasminogen Activator (t‐PA) Nanocapsules
Sign Up to like & getrecommendations! Published in 2017 at "Advanced Functional Materials"
DOI: 10.1002/adfm.201703934
Abstract: Surface modification with bioactive agents capable of combating thrombosis is a widely used strategy for developing antithrombotic biomaterials. However, exposure of the blood to the antithrombotic agent on the material surface may cause hemostatic disorders… read more here.
Keywords: thrombosis responsive; activator; surface; responsive thrombolytic ... See more keywords
Thrombin‐Anchored Bacterial Cellulose Dressing for Advanced Burn Wound Care
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Materials"
DOI: 10.1002/adma.202420338
Abstract: In burn wound surgery, commercially available dressings often lack the necessary hemostatic properties required to effectively manage hemorrhage during critical procedures, such as tangential excision of eschar. To address this limitation, a thrombin‐anchored bacterial cellulose… read more here.
Keywords: bacterial cellulose; thrombin; burn wound;
Treatment patterns and outcomes of octogenarian patients with acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Hematology"
DOI: 10.1002/ajh.25464
Abstract: REFERENCES 1. Di Nisio M, Middeldorp S, Büller HR. Direct thrombin inhibitors. New Engl J Med. 2005;353:1028-1040. 2. Lewis BE, Wallis DE, Berkowitz SD, et al. Argatroban anticoagulant therapy in patients with heparin-induced thrombocytopenia. Circulation.… read more here.
Keywords: https doi; pathol; doi org; https ... See more keywords
Ecarin based coagulation testing
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Hematology"
DOI: 10.1002/ajh.25852
Abstract: Ecarin is derived from venom of Echis carinatus, and will activate prothrombin into meizothrombin which will then cleave fibrinogen to result in clot formation. Ecarin based testing has been described for decades, but these assays… read more here.
Keywords: coagulation testing; coagulation; ecarin based; based coagulation ... See more keywords
Clinical Issues-October 2022.
Sign Up to like & getrecommendations! Published in 2022 at "AORN journal"
DOI: 10.1002/aorn.13791
Abstract: Verifying patient identity before blood product administration Key words: patient identification, patient verification, blood transfusion, blood management, wristband. Surgical site infection risk with allogeneic blood administration Key words: patient blood management, restrictive transfusion triggers, allogeneic… read more here.
Keywords: october 2022; clinical issues; issues october; blood ... See more keywords
Incorporation of a Multi-Valent Aptamer into Electrochemical Biosensors to Achieve an Improved Performance for Thrombin Analysis in Blood Serum.
Sign Up to like & getrecommendations! Published in 2022 at "ChemPlusChem"
DOI: 10.1002/cplu.202200325
Abstract: The electrochemical aptamer-based (E-AB) biosensor usually has a long reaction time when detecting thrombin. This work reports the design of an E-AB biosensor with dual recognition sites to quickly detect thrombin. Specifically, two specific recognition… read more here.
Keywords: performance; serum; tba sensor; thrombin ... See more keywords
Rapid screening and identification of anticoagulation component from carthami flos by two dimensional thrombin affinity chromatography combined with HPLC-MS/MS.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of separation science"
DOI: 10.1002/jssc.202100092
Abstract: Carthami flos, commonly known as Honghua in China, is the dried floret of safflower and widely acknowledged as a blood stasis promoting herb. The study aimed at investigating the relationship between thrombin and carthami flos… read more here.
Keywords: carthami flos; thrombin; affinity chromatography; thrombin affinity ... See more keywords
Thrombin Immobilized on Magnetic Core-Shell Mesoporous Silica Nanoparticles for Screening of the Enzyme Inhibitors From Notopterygium Incisum.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of separation science"
DOI: 10.1002/jssc.70021
Abstract: Thrombin was immobilized on magnetic core-shell mesoporous silica nanoparticles (Fe3O4@nSiO2@mSiO2) for the first time and used to screen enzyme inhibitors from extracts of Notopterygium incisum. The immobilized thrombin was characterized by Fourier-transform infrared spectroscopy, transmission… read more here.
Keywords: core shell; immobilized magnetic; magnetic core; thrombin immobilized ... See more keywords
Artificial Plateletoids Recruit Blood Proteins to Shield Symbiotic Thrombin: a Silk Fibroin/Calcium Interface Medicated Thrombin Generation and Preservation.
Sign Up to like & getrecommendations! Published in 2024 at "Small"
DOI: 10.1002/smll.202406909
Abstract: Breaking the constraints of thrombin during storage and in vivo applications remains challenging because of its low stability and sensitivity to environmental temperature and acidity. Herein, an artificial plateletoid is developed for in situ thrombin… read more here.
Keywords: silk fibroin; thrombin generation; thrombin;
The thrombin receptor PAR4 supports visceral adipose tissue inflammation
Sign Up to like & getrecommendations! Published in 2024 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-024-03097-5
Abstract: Thrombin inhibition suppresses adiposity, WAT inflammation and metabolic dysfunction in mice. Protease-activated receptor (PAR)1 does not account for thrombin-driven obesity, so we explored the culprit role of PAR4 in this context. Male WT and PAR-4-/-… read more here.
Keywords: par4; receptor; inflammation; hfd ... See more keywords
Polypyrrole-palladium nanocomposite as a high-efficiency transducer for thrombin detection with liposomes as a label
Sign Up to like & getrecommendations! Published in 2021 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-021-03673-1
Abstract: Sensitive and selective determination of protein biomarkers with high accuracy often remains a great challenge due to their existence in the human body at an exceptionally low concentration level. Therefore, sensing mechanisms that are easy… read more here.
Keywords: detection; thrombin detection; low concentration; polypyrrole palladium ... See more keywords