Timely and large dose of clotting factor IX provides better joint wound healing after hemarthrosis in hemophilia B mice
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Hematology"
DOI: 10.1007/s12185-019-02639-5
Abstract: Bleeding into the joints represents the major morbidity of severe hemophilia and predisposes it to hemophilic arthropathy (HA). In a reproducible hemarthrosis mouse model, we found distinct changes in thrombin activity in joint tissue homogenate… read more here.
Keywords: hemarthrosis; thrombin activity; clotting factor; hemophilia ... See more keywords
Amplified Electrochemical Biosensing of Thrombin Activity by RAFT Polymerization.
Sign Up to like & getrecommendations! Published in 2020 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.9b05647
Abstract: As a serine protease, thrombin is a pivotal component in coagulation cascade and has been frequently screened as an informative biomarker for the diagnosis of coagulation disorder-related diseases. Herein, a "signal-on" electrochemical biosensor is described… read more here.
Keywords: raft polymerization; chemistry; thrombin; thrombin activity ... See more keywords
Thrombin Activity in Rodent and Human Skin: Modified by Inflammation and Correlates with Innervation
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10061461
Abstract: Thrombin is present in peripheral nerves and is involved in the pathogenesis of neuropathy. We evaluated thrombin activity in skin punch biopsies taken from the paws of male mice and rats and from the legs… read more here.
Keywords: human skin; activity; inflammation; thrombin activity ... See more keywords