Oligosaccharide Blocks PAR1 (Proteinase-Activated Receptor 1)-PAR4–Mediated Platelet Activation by Binding to Thrombin Exosite II and Impairs Thrombosis
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DOI: 10.1161/atvbaha.122.318085
Abstract: Background: Inappropriate activation and aggregation of platelets can lead to arterial thrombosis. Thrombin is the most potent platelet agonist that activates human platelets via two PARs (proteinase-activated receptors), PAR1 and PAR4. The aim is to… read more here.
Keywords: thrombin exosite; mediated platelet; platelet activation; binding thrombin ... See more keywords