Coagulation in gout: is there a link with disease activity?
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Rheumatology"
DOI: 10.1007/s10067-022-06047-9
Abstract: To investigate the coagulation system in gout patients and associations between disease activity and levels of coagulation markers. A prospective cohort study was performed with data from 30 Dutch gout patients. Levels of coagulation markers… read more here.
Keywords: disease activity; coagulation; thrombin generation; activity ... See more keywords
Standardization and evaluation of the performance of the thrombin generation test under hypo- and hypercoagulability conditions
Sign Up to like & getrecommendations! Published in 2018 at "Hematology, Transfusion and Cell Therapy"
DOI: 10.1016/j.htct.2018.08.007
Abstract: Background In order to standardize a thrombin generation() protocol, we analyzed the analytical variables and sensitivity of this test to hypo/hypercoagulability states. Methods The effect of the tissue factor concentration and the intra- and interassay… read more here.
Keywords: generation; generation test; evaluation; thrombin generation ... See more keywords
Platelet function, but not thrombin generation, is impaired in acute normovolemic hemodilution (ANH) blood.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of clinical anesthesia"
DOI: 10.1016/j.jclinane.2019.04.032
Abstract: STUDY OBJECTIVE We investigated the coagulation changes that might occur in acute normovolemic hemodilution (ANH) blood over several hours during cardiac surgery requiring cardiopulmonary bypass. DESIGN This study was a prospective observational study. SETTING This… read more here.
Keywords: anh blood; study; platelet; thrombin generation ... See more keywords
Enhanced thrombin generation in patients with arterial hypertension.
Sign Up to like & getrecommendations! Published in 2019 at "Thrombosis research"
DOI: 10.1016/j.thromres.2018.11.027
Abstract: BACKGROUND Arterial hypertension is associated with greater risk of cardiovascular diseases and thrombotic complications, suggesting that hypertension is a prothrombotic state. OBJECTIVES To investigate the relationship between arterial hypertension and thrombin generation, and between blood… read more here.
Keywords: arterial hypertension; blood pressure; thrombin generation; hypertension ... See more keywords
Mathematical model of thrombin generation and bleeding phenotype in Amish carriers of Factor IX:C deficiency vs. controls.
Sign Up to like & getrecommendations! Published in 2019 at "Thrombosis research"
DOI: 10.1016/j.thromres.2019.07.020
Abstract: INTRODUCTION Factor IX:C (FIX:C) levels vary in hemophilia B carriers even in pedigrees with a unifying genetic defect. Analyzing the balance between pro-and anticoagulants might increase our understanding of carriers' bleeding potential. AIM In this… read more here.
Keywords: fix; thrombin generation; mathematical model;
Thrombin generation, thrombin-antithrombin complex, and prothrombin fragment F1+2 as biomarkers for hypercoagulability in cancer patients.
Sign Up to like & getrecommendations! Published in 2019 at "Thrombosis research"
DOI: 10.1016/j.thromres.2019.12.018
Abstract: BACKGROUND Thrombin generation, thrombin-antithrombin complex (TAT) levels, and prothrombin fragment 1+2 (F1+2) have shown potential as biomarkers of thromboembolic risk. The aims were to establish reference intervals for these three biomarkers and to assess the… read more here.
Keywords: cancer; cancer patients; tat; thrombin generation ... See more keywords
Point-of-Care Platform for Diagnosis of Venous Thrombosis by Simultaneous Detection of Thrombin Generation and D-Dimer in Human Plasma
Sign Up to like & getrecommendations! Published in 2022 at "Analytical Chemistry"
DOI: 10.1021/acs.analchem.2c03819
Abstract: Venous thromboembolism (VTE) refers to a blood clot that starts in a vein. The risk of developing VTE is highest after major surgery or a major injury, or when someone has heart failure, cancer, or… read more here.
Keywords: thrombin generation; platform; generation dimer; dimer ... See more keywords
Identification and characterization of a factor Va-binding site on human prothrombin fragment 2
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-38857-4
Abstract: The fragment 2 domain (F2) of prothrombin and its interaction with factor (F) Va is known to contribute significantly to prothrombinase-catalyzed activation of prothrombin. The extent to which the F2-FVa interaction affects the overall thrombin… read more here.
Keywords: prothrombin; fva; thrombin generation; fragment ... See more keywords
Assessment of DOAC in GEriatrics ( Adage Study): Rivaroxaban/Apixaban Concentrations and Thrombin Generation Profiles in NVAF Very Elderly Patients
Sign Up to like & getrecommendations! Published in 2022 at "Thrombosis and Haemostasis"
DOI: 10.1055/a-1981-1763
Abstract: Background  Although a growing number of very elderly patients with atrial fibrillation (AF), multiple conditions, and polypharmacy receive direct oral anticoagulants (DOACs), few studies specifically investigated both apixaban/rivaroxaban pharmacokinetics and pharmacodynamics in such patients. Aims… read more here.
Keywords: thrombin generation; rivaroxaban apixaban; elderly patients; adage ... See more keywords
Sensitive measurement of clinically relevant factor VIII levels in thrombin generation assays requires presence of factor XIa.
Sign Up to like & getrecommendations! Published in 2023 at "Thrombosis and haemostasis"
DOI: 10.1055/a-2101-7961
Abstract: BACKGROUND Hemophilia A (HA) is characterized by decreased or absent FVIII. Current FVIII assays are based on clotting time and only provide information about the initiation of coagulation. In contrast, thrombin generation assays (TGA) can… read more here.
Keywords: thrombin generation; fviii; generation; generation assays ... See more keywords
Understanding the Effects of NOAC Combined with Antiplatelet Therapy on Clot Kinetics.
Sign Up to like & getrecommendations! Published in 2019 at "Thrombosis and haemostasis"
DOI: 10.1055/s-0039-1696645
Abstract: The pharmacodynamic effects of oral anticoagulants (OACs) on the coagulation pathway and the effect of antiplatelet therapy (APT) on platelet activation, used in isolation, have been extensively investigated. However, OAC and APT are now frequently… read more here.
Keywords: clot; dapt; effect; thrombin generation ... See more keywords