Thrombin inhibitor argatroban modulates bone marrow stromal cells behaviors and promotes osteogenesis through canonical Wnt signaling.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119073
Abstract: AIMS Coagulation is a common event that play a double-edged role in physiological and pathological process. Anti-coagulation methods were applied in joint surgery or scaffolds implantation to encourage new vascular formation and avoid coagulation block.… read more here.
Keywords: argatroban; coagulation; inhibitor argatroban; marrow stromal ... See more keywords
Insights in to the mechanism of interaction of a thrombin inhibitor, dabigatran etexilate with human serum albumin and influence of β-cyclodextrin on binding: Spectroscopic and computational approach
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2017.12.056
Abstract: Abstract The present work investigates the characteristics of interaction of a thrombin inhibitor, dabigatran etexilate (DAB) with a model transport protein, human serum albumin (HSA). In vitro studies on DAB-HSA interactions were carried out by… read more here.
Keywords: thrombin inhibitor; inhibitor dabigatran; human serum; dabigatran etexilate ... See more keywords
Identify thrombin inhibitor with novel skeleton based on virtual screening study
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2020.1815580
Abstract: Abstract Virtual screening refers to the screening of active compounds based on a small-molecule database. This procedure can rapidly select active compounds with pharmaceutical properties from millions of molecules, thus considerably reducing the number of… read more here.
Keywords: screening; identify thrombin; novel skeleton; virtual screening ... See more keywords
Atrial Fibrillation in a Patient with Heparin-induced Thrombocytopenia Successfully Treated by Radiofrequency Catheter Ablation Using a Direct Thrombin Inhibitor
Sign Up to like & getrecommendations! Published in 2022 at "Internal Medicine"
DOI: 10.2169/internalmedicine.9288-21
Abstract: A 74-year-old man was admitted to our hospital to undergo radiofrequency catheter ablation (RFCA) of persistent atrial fibrillation (AF). We found that he had a history of heparin-induced thrombocytopenia (HIT). Thus, a direct thrombin inhibitor,… read more here.
Keywords: thrombin inhibitor; direct thrombin; radiofrequency catheter; catheter ablation ... See more keywords