Anthraquinones from Cassiae semen as thrombin inhibitors: in vitro and in silico studies.
Sign Up to like & getrecommendations! Published in 2019 at "Phytochemistry"
DOI: 10.1016/j.phytochem.2019.04.018
Abstract: Thrombin inhibitor therapy is one of the most effective therapeutic strategies for the prevention and treatment of cardiovascular and thrombotic diseases. Although several marketed direct thrombin inhibitors (DTIs) have been widely used in clinic, the… read more here.
Keywords: aurantio obtusin; thrombin inhibitors; cassiae semen; anthraquinones cassiae ... See more keywords
SUBSEQUENT CHANGES IN DOSING REQUIREMENTS TO PRODUCE THERAPEUTIC ANTICOAGULATION WITH INJECTABLE DIRECT THROMBIN INHIBITORS AFTER INSTITUTIONAL CHANGE TO THE ACTIVATED PARTIAL THROMBOPLASTIN TIME REAGENT
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(18)32645-7
Abstract: Injectable direct thrombin inhibitors (iDTI) argatroban and bivalirudin are useful in the management of patients with documented or suspected heparin induced thrombocytopenia (HIT). Management of iDTIs includes monitoring with the activated partial thromboplastin time (aPTT)… read more here.
Keywords: thromboplastin time; direct thrombin; injectable direct; thrombin inhibitors ... See more keywords
Discovery of novel N-acylpyrazoles as potent and selective thrombin inhibitors.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.2139/ssrn.4202449
Abstract: Direct oral anticoagulants (DOACs), which includes thrombin and factor Xa inhibitors, have emerged as the preferred therapeutics for thrombotic disorders, penetrating a market previously dominated by warfarin and heparin. This article describes the discovery and… read more here.
Keywords: novel acylpyrazoles; discovery novel; thrombin inhibitors; acylpyrazoles potent ... See more keywords
An overview of thrombin inhibitors in the perspective of structure-activity relationships.
Sign Up to like & getrecommendations! Published in 2022 at "Current medicinal chemistry"
DOI: 10.2174/0929867329666220906105200
Abstract: Thrombosis is one of the most important pathogenic factors that related to cardiovascular diseases. Presently, thrombin inhibitors have gradually gained prominence in clinical practice due to their unique potential, such as dabigatran. Nevertheless, the risk… read more here.
Keywords: thrombin inhibitors; structure activity; structure; activity relationships ... See more keywords
Pyrazole-Based Thrombin Inhibitors with a Serine-Trapping Mechanism of Action: Synthesis and Biological Activity
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15111340
Abstract: New antithrombotic drugs are needed to combat thrombosis, a dangerous pathology that causes myocardial infarction and ischemic stroke. In this respect, thrombin (FIIa) represents an important drug target. We herein report the synthesis and biological… read more here.
Keywords: synthesis biological; thrombin inhibitors; biological activity; inhibitors serine ... See more keywords