Thrombin‐PAR1 signaling in pancreatic cancer promotes an immunosuppressive microenvironment
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DOI: 10.1111/jth.15115
Abstract: Essentials Elimination of PDAC tumor cell PAR1 increased cytotoxic T cells and reduced tumor macrophages. PAR1KO PDAC cells are preferentially eliminated from growing tumors. Thrombin‐PAR1 signaling in PDAC tumor cells drives an immunosuppressive gene signature.… read more here.
Keywords: thrombin par1; par1 signaling; pdac tumor; par1 ... See more keywords