Thromboinflammation in Brain Ischemia: Recent Updates and Future Perspectives
Sign Up to like & getrecommendations! Published in 2022 at "Stroke"
DOI: 10.1161/strokeaha.122.038733
Abstract: Despite decades of promising preclinical validation and clinical translation, ischemic stroke still remains as one of the leading causes of death and disability worldwide. Within its complex pathophysiological signatures, thrombosis and inflammation, that is, thromboinflammation,… read more here.
Keywords: thromboinflammation; thromboinflammation brain; updates future; brain ischemia ... See more keywords
The Ectopyrase CD73 Is a Critical Checkpoint in Thromboinflammation
Sign Up to like & getrecommendations! Published in 2024 at "Blood"
DOI: 10.1182/blood-2024-200189
Abstract: Introduction: Purinergic signaling through extracellular nucleotides such as adenosine is at the intersection of inflammation and coagulation pathways. CD73 is the key vascular enzyme involved generating AMP-derived extracellular adenosine to reduce inflammation, but its impact… read more here.
Keywords: cd73; mice; checkpoint; history ... See more keywords
Tissue factor bearing microparticles drive thromboinflammation and predict DIC and mortality in sepsis: Results from the roadmap-sepsis study
Sign Up to like & getrecommendations! Published in 2025 at "Blood"
DOI: 10.1182/blood-2025-1302
Abstract: Background: Thromboinflammation is recognized as a central pathological process in sepsis. Sepsis-induced inflammation, triggered by bacterial infection, is tightly linked to a hypercoagulable state and endothelial cell activation. The failure of natural anticoagulant pathways—due to… read more here.
Keywords: thromboinflammation; dic group; study; sepsis ... See more keywords
Endothelial cell activation enhances thromboinflammation in vaccine-induced immune thrombotic thrombocytopenia
Sign Up to like & getrecommendations! Published in 2025 at "Blood Advances"
DOI: 10.1182/bloodadvances.2024014165
Abstract: Key Points • Exposure of endothelial cells to serum or IgG from patients with VITT induced TF expression and thromboinflammation.• The Endo-chip provides a tool for the study of endothelial involvement in immune thrombotic disorders. read more here.
Keywords: cell activation; enhances thromboinflammation; immune thrombotic; activation enhances ... See more keywords
Inhibition of SARS-CoV-2-mediated thromboinflammation by CLEC2.Fc.
Sign Up to like & getrecommendations! Published in 2023 at "EMBO molecular medicine"
DOI: 10.15252/emmm.202216351
Abstract: Thromboinflammation is the major cause of morbidity and mortality in COVID-19 patients, and post-mortem examination demonstrates the presence of platelet-rich thrombi and microangiopathy in visceral organs. Moreover, persistent microclots were detected in both acute COVID-19… read more here.
Keywords: clec2; cov induced; sars cov; net formation ... See more keywords
Venous Air Embolism Activates Complement C3 Without Corresponding C5 Activation and Trigger Thromboinflammation in Pigs
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.839632
Abstract: Introduction Air embolism may complicate invasive medical procedures. Bubbles trigger complement C3-mediated cytokine release, coagulation, and platelet activation in vitro in human whole blood. Since these findings have not been verified in vivo, we aimed… read more here.
Keywords: air embolism; complement; air; activation ... See more keywords
Extracellular Vesicles: New Players in the Mechanisms of Sepsis- and COVID-19-Related Thromboinflammation
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24031920
Abstract: Sepsis and COVID-19 patients often manifest an imbalance in inflammation and coagulation, a complex pathological mechanism also named thromboinflammation, which strongly affects patient prognosis. Extracellular vesicles (EVs) are nanoparticles released by cells into extracellular space… read more here.
Keywords: sepsis; extracellular vesicles; sepsis covid; thromboinflammation ... See more keywords
MiR-146a Contributes to Thromboinflammation and Recurrence in Young Patients with Acute Myocardial Infarction
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm12071185
Abstract: Studies on older patients have established notable conceptual changes in the etiopathogenesis of acute coronary syndrome (ACS), but little is known about this disease in young patients ( Q2 and T allele) had a two-fold… read more here.
Keywords: cith3 dna; mir 146a; young patients; recurrence ... See more keywords
Low-Molecular-Weight Fucoidan Inhibits Thromboinflammation and Ameliorates Deep Vein Thrombosis via Targeting S100A8/A9
Sign Up to like & getrecommendations! Published in 2025 at "Marine Drugs"
DOI: 10.3390/md23050180
Abstract: Deep vein thrombosis (DVT) is a prevalent life-threatening complication among hospitalized patients. DVT is characterized by the hypercoagulability and thromboinflammation in which platelet activation and neutrophil extracellular trap (NET) formation are critically involved. Studies have… read more here.
Keywords: deep vein; low molecular; molecular weight; vein thrombosis ... See more keywords
Mechanisms of Thromboinflammation in Viral Infections—A Narrative Review
Sign Up to like & getrecommendations! Published in 2025 at "Viruses"
DOI: 10.3390/v17091207
Abstract: The circulatory and immune systems function in close coordination to maintain homeostasis and act as a frontline defense against infections. However, under certain conditions, this interaction becomes dysregulated, leading to thromboinflammation, a pathological process marked… read more here.
Keywords: review; infections narrative; thromboinflammation viral; viral infections ... See more keywords