Value of Thrombomodulin as a Marker for Sepsis in Critically Ill Children
Sign Up to like & getrecommendations! Published in 2020 at "Indian Journal of Pediatrics"
DOI: 10.1007/s12098-020-03564-w
Abstract: Pediatric sepsis is altered organ function in critically ill children and a main etiology of mortality for children. Therefore, the authors aimed to assess the role of serum thrombomodulin as valuable biomarker in the diagnosis… read more here.
Keywords: sepsis; ill children; mortality; critically ill ... See more keywords
Thrombomodulin (TM) in tumor cell differentiation and periphery blood immune microenvironment in oral squamous cell carcinoma.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical immunology"
DOI: 10.1016/j.clim.2018.02.011
Abstract: Thrombomodulin (TM, also known as CD141), which functions as an anticoagulant, is widely expressed on cell surface of a variety of cell types, including human blood cells as well as certain immune cells. To determine… read more here.
Keywords: oscc patients; cd141 dcs; blood; thrombomodulin ... See more keywords
Allosteric Modulation of Thrombin by Thrombomodulin: Insights from Logistic Regression and Statistical Analysis of Molecular Dynamics Simulations
Sign Up to like & getrecommendations! Published in 2024 at "ACS Omega"
DOI: 10.1021/acsomega.4c03375
Abstract: Thrombomodulin (TM), a transmembrane receptor integral to the anticoagulant pathway, governs thrombin’s substrate specificity via interaction with thrombin’s anion-binding exosite I. Despite its established role, the precise mechanisms underlying this regulatory function are yet to… read more here.
Keywords: thrombin; thrombomodulin; thrombin thrombomodulin; modulation thrombin ... See more keywords
Thrombomodulin is upregulated in the kidneys of women with pre-eclampsia
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-85040-9
Abstract: The endothelial glycoprotein thrombomodulin regulates coagulation, vascular inflammation and apoptosis. In the kidney, thrombomodulin protects the glomerular filtration barrier by eliciting crosstalk between the glomerular endothelium and podocytes. Several glomerular pathologies are characterized by a… read more here.
Keywords: thrombomodulin expression; kidneys women; glomerular thrombomodulin; pre eclampsia ... See more keywords
Identification of the novel G250R variant indicates a role for Thrombomodulin in modulating the risk for venous thromboembolism.
Sign Up to like & getrecommendations! Published in 2022 at "Thrombosis and haemostasis"
DOI: 10.1055/a-1827-7109
Abstract: Thrombomodulin displays anticoagulant properties through thrombin binding and protein C activation. In close relatives who had a history of recurrent VTE, a missense variant (G250R) in the EGF-1 domain was identified. In an asymptomatic 250R… read more here.
Keywords: role thrombomodulin; variant; g250r; thrombomodulin ... See more keywords
1607: EFFECTS OF RECOMBINANT HUMAN THROMBOMODULIN ON NET FORMATION IN ORGANS OF SEPTIC MICE
Sign Up to like & getrecommendations! Published in 2019 at "Critical Care Medicine"
DOI: 10.1097/01.ccm.0000552349.22349.cc
Abstract: Learning Objectives: Neutrophil extracellular traps (NETs) are important for local defense against invading pathogens. Excessive systemic NET formation, however, could induced coagulopathy, microcirculatory dysfunction, and organ damage. Consistent with this, NETs have been reported to… read more here.
Keywords: septic mice; formation; rtm group; thrombomodulin ... See more keywords
Management of Major Orthopaedic Surgery in a Patient With the Rare Thrombomodulin c.1611C>a Mutation: A Case of an Uncommon Bleeding Disorder
Sign Up to like & getrecommendations! Published in 2025 at "Haemophilia"
DOI: 10.1111/hae.70042
Abstract: The 1611C > A variant in thrombomodulin is associated with a very rare autosomal dominant bleeding disorder [1, 2]. This mutation leads to the synthesis of a truncated TM which has lost the last three… read more here.
Keywords: surgery; orthopaedic surgery; thrombomodulin; mutation ... See more keywords
Downregulation of thrombomodulin contributes to ischemia‐reperfusion injury in mice with steatotic liver
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology Research"
DOI: 10.1111/hepr.13802
Abstract: Ischemia‐reperfusion (IR) injury is one of the most critical complications commonly associated with liver surgery, including liver transplantation. Steatotic livers are particularly vulnerable to IR injury. However, the underlying mechanisms of this increased susceptibility have… read more here.
Keywords: reperfusion injury; liver; injury; ischemia reperfusion ... See more keywords
Impact of Laparoscopic Sleeve Gastrectomy on Thrombomodulin Concentration and Early Markers of Atherosclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Interventional Cardiology"
DOI: 10.1155/2022/6152571
Abstract: Background Thrombomodulin, an integral membrane protein functioning as a cofactor in the anticoagulant pathways, has recently emerged as a marker of endothelial dysfunction. This study aimed to investigate the impact of laparoscopic sleeve gastrectomy (LSG)… read more here.
Keywords: laparoscopic sleeve; impact laparoscopic; thrombomodulin; sleeve gastrectomy ... See more keywords
Thrombomodulin Switches Signaling and Protease-Activated Receptor 1 Cleavage Specificity of Thrombin
Sign Up to like & getrecommendations! Published in 2024 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.123.320185
Abstract: BACKGROUND: Cleavage of the extracellular domain of PAR1 (protease-activated receptor 1) by thrombin at Arg41 and by APC (activated protein C) at Arg46 initiates paradoxical cytopathic and cytoprotective signaling in endothelial cells. In the latter… read more here.
Keywords: receptor; thrombomodulin; par1; specificity ... See more keywords
High fat diet delays plasmin generation in a thrombomodulin-dependent manner in mice.
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood.2019004267
Abstract: Obesity is a prevalent prothrombotic risk factor marked by enhanced fibrin formation and suppressed fibrinolysis. Fibrin both promotes thrombotic events and drives obesity pathophysiology, but a lack of essential analytical tools has left fibrinolytic mechanisms… read more here.
Keywords: hfd; fat diet; generation; plasmin generation ... See more keywords