The structure, function, and clinical use of the thrombopoietin receptor agonist avatrombopag.
Sign Up to like & getrecommendations! Published in 2021 at "Blood reviews"
DOI: 10.1016/j.blre.2021.100909
Abstract: Thrombopoietin regulates platelet production through activation of the thrombopoietin receptor (TPO-R). TPO-R agonists (TPO-RAs) are available to treat thrombocytopenia in chronic immune thrombocytopenia (ITP), chronic liver disease (CLD) patients who are undergoing a procedure, severe… read more here.
Keywords: thrombopoietin; avatrombopag; tpo; thrombopoietin receptor ... See more keywords
Pharmacokinetics of Lusutrombopag, a Novel Thrombopoietin Receptor Agonist, in Rats by UPLC-MS/MS
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Analytical Chemistry"
DOI: 10.1155/2020/7290470
Abstract: Lusutrombopag is a second oral thrombopoietin (TPO) receptor agonist that selectively acts on human TPO receptors. In the study, UPLC-MS/MS was used to establish a selective and sensitive method to determine lusutrombopag with poziotinib as… read more here.
Keywords: receptor agonist; thrombopoietin; lusutrombopag poziotinib; lusutrombopag ... See more keywords
Thrombopoietin mutation in congenital amegakaryocytic thrombocytopenia treatable with romiplostim
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DOI: 10.15252/emmm.201708168
Abstract: Congenital amegakaryocytic thrombocytopenia (CAMT) is an inherited disorder characterized at birth by thrombocytopenia with reduced megakaryocytes, which evolves into generalized bone marrow aplasia during childhood. Although CAMT is genetically heterogeneous, mutations of MPL, the gene… read more here.
Keywords: thrombopoietin; thrombocytopenia; congenital amegakaryocytic; amegakaryocytic thrombocytopenia ... See more keywords
Clinical efficacy of avatrombopag and recombinant human thrombopoietin in the treatment of chronic liver disease-associated severe thrombocytopenia: A real-world study
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1009612
Abstract: Purpose: To investigate the clinical efficacy of avatrombopag, an oral thrombopoietin receptor agonist, versus subcutaneous recombinant human thrombopoietin (rh-TPO) in the treatment of severe thrombocytopenia (TCP) associated with chronic liver disease (CLD). Methods: Clinical data… read more here.
Keywords: thrombopoietin; efficacy avatrombopag; efficacy; clinical efficacy ... See more keywords
Development of an Automated Chemiluminescent Enzyme Immunoassay for Measuring Thrombopoietin in Human Plasma
Sign Up to like & getrecommendations! Published in 2022 at "Diagnostics"
DOI: 10.3390/diagnostics12020313
Abstract: Plasma thrombopoietin (TPO) measurements help distinguish between different types of thrombocytopenia but are not feasible in routine clinical practice. We developed a fully automated quantitative chemiluminescent enzyme immunoassay (CLEIA) for measuring TPO (TPO-CLEIA), which is… read more here.
Keywords: thrombopoietin; human plasma; tpo; enzyme immunoassay ... See more keywords