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   Articles with "thrombospondin" as a keyword



Spatiotemporal distribution of thrombospondin-4 and -5 in cartilage during endochondral bone formation and repair.

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recommendations! Published in 2021 at "Bone"

DOI: 10.1016/j.bone.2021.115999

Abstract: During skeletal development most bones are first formed as cartilage templates, which are gradually replaced by bone. If later in life those bones break, temporary cartilage structures emerge to bridge the fractured ends, guiding the… read more here.

Keywords: bone formation; bone; cartilage; tsp ... See more keywords

Thrombospondin-4 deletion does not exacerbate muscular dystrophy in β-sarcoglycan-deficient and laminin α2 chain-deficient mice

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recommendations! Published in 2024 at "Scientific Reports"

DOI: 10.1038/s41598-024-65473-8

Abstract: Muscular dystrophy is a group of genetic disorders that lead to muscle wasting and loss of muscle function. Identifying genetic modifiers that alleviate symptoms or enhance the severity of a primary disease helps to understand… read more here.

Keywords: deletion; thrombospondin; pathology; dystrophy ... See more keywords

O-fucosylation of thrombospondin type I repeats is dispensable for trafficking thrombospondin 1 to platelet secretory granules.

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recommendations! Published in 2023 at "Glycobiology"

DOI: 10.1093/glycob/cwad006

Abstract: Thrombospondin 1 (THBS1) is a secreted extracellular matrix glycoprotein that regulates a variety of cellular and physiological processes. THBS1's diverse functions are attributed to interactions between the modular domains of THBS1 with an array of… read more here.

Keywords: pofut2; type repeats; thbs1; secretory granules ... See more keywords

Thrombospondin-2 predicts response to treatment with intravenous immunoglobulin in children with Kawasaki disease

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recommendations! Published in 2018 at "BMJ Paediatrics Open"

DOI: 10.1136/bmjpo-2017-000190

Abstract: Objective To investigate the predictive value of thrombospondin-2 (TSP-2) in assessing the response to intravenous immunoglobulin (IVIG) in children with acute Kawasaki disease (KD). Methods This was a cohort study with controls. 71 children with… read more here.

Keywords: intravenous immunoglobulin; plasma tsp; kawasaki disease; ivig ... See more keywords

Thrombospondin-1 Plays a Major Pathogenic Role in Experimental and Human Bronchopulmonary Dysplasia.

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recommendations! Published in 2022 at "American journal of respiratory and critical care medicine"

DOI: 10.1164/rccm.202104-1021oc

Abstract: RATIONALE Extremely preterm infants develop bronchopulmonary dysplasia (BPD), a chronic lung injury that lacks effective treatment. Thrombospondin-1 is an anti-angiogenic protein that activates TGF-β1, a cytokine strongly linked to both experimental and human BPD. OBJECTIVES… read more here.

Keywords: lung; pathogenic role; thrombospondin; experimental human ... See more keywords

Hypoxia Inhibits Subretinal Inflammation Resolution Thrombospondin-1 Dependently

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23020681

Abstract: Hypoxia is potentially one of the essential triggers in the pathogenesis of wet age-related macular degeneration (wetAMD), characterized by choroidal neovascularization (CNV) which is driven by the accumulation of subretinal mononuclear phagocytes (MP) that include… read more here.

Keywords: thrombospondin; inflammation resolution; subretinal inflammation; resolution ... See more keywords

Molecular characterization and expression of a disintegrin and metalloproteinase with thrombospondin motifs 8 in chicken

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recommendations! Published in 2018 at "Asian-Australasian Journal of Animal Sciences"

DOI: 10.5713/ajas.18.0265

Abstract: Objective A disintegrin and metallopeptidase with thrombospondin motifs type 8 (ADAMTS8) is crucial for diverse physiological processes, such as inflammation, tissue morphogenesis, and tumorigenesis. The chicken ADAMTS8 (chADAMTS8) gene was differentially expressed in the kidney… read more here.

Keywords: thrombospondin motifs; disintegrin; expression; gene ... See more keywords

Differential regulation by CD47 and thrombospondin-1 of extramedullary erythropoiesis in mouse spleen

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recommendations! Published in 2024 at "eLife"

DOI: 10.7554/elife.92679

Abstract: Extramedullary erythropoiesis is not expected in healthy adult mice, but erythropoietic gene expression was elevated in lineage-depleted spleen cells from Cd47−/− mice. Expression of several genes associated with early stages of erythropoiesis was elevated in… read more here.

Keywords: committed erythroid; thrombospondin; extramedullary erythropoiesis; cd47 ... See more keywords