O-fucosylation of thrombospondin type I repeats is dispensable for trafficking thrombospondin 1 to platelet secretory granules.
Sign Up to like & getrecommendations! Published in 2023 at "Glycobiology"
DOI: 10.1093/glycob/cwad006
Abstract: Thrombospondin 1 (THBS1) is a secreted extracellular matrix glycoprotein that regulates a variety of cellular and physiological processes. THBS1's diverse functions are attributed to interactions between the modular domains of THBS1 with an array of… read more here.
Keywords: pofut2; type repeats; thbs1; secretory granules ... See more keywords
An Indirect Immunofluorescence Method Facilitates Detection of Thrombospondin Type 1 Domain-Containing 7A-Specific Antibodies in Membranous Nephropathy.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2016010050
Abstract: Thrombospondin type 1 domain-containing 7A (THSD7A) is a target antigen identified in adult membranous nephropathy (MN) along with the major antigen phospholipase A2 receptor 1 (PLA2R1). The prevalence of THSD7A-Ab-positive patients is unknown, and it… read more here.
Keywords: domain containing; type domain; thsd7a associated; membranous nephropathy ... See more keywords
A Heterologous Model of Thrombospondin Type 1 Domain-Containing 7A-Associated Membranous Nephropathy.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2017010030
Abstract: Thrombospondin type 1 domain-containing 7A (THSD7A) is a target for autoimmunity in patients with membranous nephropathy (MN). Circulating autoantibodies from patients with THSD7A-associated MN have been demonstrated to cause MN in mice. However, THSD7A-associated MN… read more here.
Keywords: domain containing; type domain; thrombospondin type; membranous nephropathy ... See more keywords
Thrombospondin Type 1 Domain-Containing 7A Localizes to the Slit Diaphragm and Stabilizes Membrane Dynamics of Fully Differentiated Podocytes.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2018090941
Abstract: BACKGROUND About 3%-5% of adults with membranous nephropathy have autoantibodies directed against thrombospondin type 1 domain-containing 7A (THSD7A), a podocyte-expressed transmembrane protein. However, the temporal and spatial expression of THSD7A and its biologic function for… read more here.
Keywords: expression; thrombospondin type; slit diaphragm; slit ... See more keywords
Research progress of thrombospondin type-1 domain-containing 7A in membranous nephropathy
Sign Up to like & getrecommendations! Published in 2018 at "International Urology and Nephrology"
DOI: 10.3760/cma.j.issn.1673-4416.2018.02.041
Abstract: 膜性肾病类型的鉴别对于研究肾病综合征的发病机制、诊断、治疗以及疾病的预后均有重要意义。1型血小板反应蛋白7A域(thrombospondin type－1 domain－containing 7A，THSD7A)首先在人脐静脉内皮细胞(human umbilical vein，HUVECs)中被发现，并证实THSD7A有抑制HUVECs的迁移和血管形成的作用。近来，利用免疫病理技术鉴别原发性膜性肾病和继发性膜性肾病已有较大进展。相关研究提出THSD7A可作为欧洲和美国的膜性肾病的新的靶抗原，之后THSD7A在膜性肾病中的相关研究越来越多。本文旨在综合近期膜性肾病THSD7A的研究进展。 read more here.
Keywords: domain containing; type domain; thrombospondin type;