Thromboxane A2 receptor signaling in endothelial cells attenuates monocrotaline-induced liver injury.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology and applied pharmacology"
DOI: 10.1016/j.taap.2019.114733
Abstract: Sinusoidal obstruction syndrome (SOS) is a major complication of chemotherapy and hematopoietic stem cell transplantation. The early stage of SOS is characterized by liver sinusoidal endothelial cell (LSEC) injury accompanied by platelet aggregation. Thromboxane A2… read more here.
Keywords: mct; induced liver; thromboxane; liver injury ... See more keywords
The Aspirin Regimens in Essential Thrombocythemia (ARES) phase II randomized trial design: Implementation of the serum thromboxane B2 assay as an evaluation tool of different aspirin dosing regimens in the clinical setting
Sign Up to like & getrecommendations! Published in 2018 at "Blood Cancer Journal"
DOI: 10.1038/s41408-018-0078-3
Abstract: Once-daily (od), low-dose aspirin (75–100 mg) is recommended to reduce the thrombotic risk of patients with essential thrombocytemia (ET). This practice is based on data extrapolated from other high-risk patients and an aspirin trial in polycythemia… read more here.
Keywords: aspirin regimens; trial; serum; aspirin ... See more keywords
Genetic Depletion of Thromboxane A2/Thromboxane-Prostanoid Receptor Signalling Prevents Microvascular Dysfunction in Ischaemia/Reperfusion Injury.
Sign Up to like & getrecommendations! Published in 2018 at "Thrombosis and haemostasis"
DOI: 10.1055/s-0038-1672206
Abstract: OBJECTIVE Activation of thromboxane A2 synthase (TXAS)/thromboxane A2 (TXA2)/thromboxane prostanoid (TP) receptor leads to arterial constriction, platelet aggregation and vascular injury. We attempted to characterize the microvascular dysfunction in ischaemia/reperfusion injury using genetically modified TXAS-/-,… read more here.
Keywords: injury; txas; ischaemia reperfusion; thromboxane ... See more keywords
A Thromboxane A2 Receptor-Driven COX-2–Dependent Feedback Loop That Affects Endothelial Homeostasis and Angiogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.121.317380
Abstract: Background: TP (thromboxane A2 receptor) plays an eminent role in the pathophysiology of endothelial dysfunction and cardiovascular disease. Moreover, its expression is reported to increase in the intimal layer of blood vessels of cardiovascular high-risk… read more here.
Keywords: receptor; thromboxane; dependent feedback; feedback loop ... See more keywords
Aspirin suppresses hepatic glucagon signaling through decreasing production of thromboxane A2.
Sign Up to like & getrecommendations! Published in 2023 at "Endocrinology"
DOI: 10.1210/endocr/bqac217
Abstract: Excessive hepatic glucose production (HGP) is a major cause of fasting hyperglycemia in diabetes and antihyperglycemic therapy takes center stage. Nonsteroidal anti-inflammatory drugs (NSAIDs), such as acetylsalicylic acid(Aspirin), reduce hyperglycemia caused by unrestrained gluconeogenesis in… read more here.
Keywords: glucagon signaling; thromboxane; production; gluconeogenesis ... See more keywords
1213-P: A Novel Relationship between Thromboxane A2 Receptor and Obesity-Related Inflammation
Sign Up to like & getrecommendations! Published in 2021 at "Diabetes"
DOI: 10.2337/db21-1213-p
Abstract: Animal models of obesity have shown that the expression of Thromboxane A2 Receptor (tbxa2r) and thromboxane synthase (Tbxas1) are increased in adipose tissue (AT) and are associated with insulin resistance and inflammation. Objective: To compare… read more here.
Keywords: none; inflammation; obesity related; thromboxane receptor ... See more keywords
Aspirin Inhibits the Inflammatory Response of Protease-Activated Receptor 1 in Pregnancy Neutrophils: Implications for Treating Women with Preeclampsia
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232113218
Abstract: Neutrophils expressing cyclooxygenase-2 (COX-2) extensively infiltrate maternal blood vessels in preeclampsia, associated with vascular inflammation. Because pregnancy neutrophils also express protease-activated receptor 1 (PAR-1, F2R thrombin receptor), which they do not in non-pregnant subjects, they… read more here.
Keywords: receptor; pregnancy neutrophils; thromboxane; protease activated ... See more keywords
Increased Thromboxane A2 Levels in Pulmonary Artery Smooth Muscle Cells Isolated from Patients with Chronic Obstructive Pulmonary Disease
Sign Up to like & getrecommendations! Published in 2023 at "Medicina"
DOI: 10.3390/medicina59010165
Abstract: Introduction: Pulmonary hypertension due to chronic obstructive pulmonary disease (COPD) is classified as Group 3 pulmonary hypertension, with no current proven targeted therapies. It has been shown that cigarette smoke, the main risk factor for… read more here.
Keywords: muscle cells; thromboxane; artery smooth; pulmonary artery ... See more keywords
The Role and Regulation of Thromboxane A2 Signaling in Cancer-Trojan Horses and Misdirection
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27196234
Abstract: Over the last two decades, there has been an increasing awareness of the role of eicosanoids in the development and progression of several types of cancer, including breast, prostate, lung, and colorectal cancers. Several processes… read more here.
Keywords: role regulation; role; txa2 signaling; thromboxane ... See more keywords