A Predictive Model of Thrombus Growth in Stenosed Vessels with Dynamic Geometries
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Medical and Biological Engineering"
DOI: 10.1007/s40846-018-0443-5
Abstract: This paper introduces a dynamic model of platelet-rich thrombus growth in stenosed vessels using computational fluid dynamics methods. Platelet adhesion, aggregation and activation kinetics are modeled by solving mass transport equations for blood components involved… read more here.
Keywords: thrombus growth; stenosed vessels; model; growth ... See more keywords
A Computational Model of Thrombus Growth Based on Level Set Method
Sign Up to like & getrecommendations! Published in 2021 at "IEEE Access"
DOI: 10.1109/access.2021.3091556
Abstract: The computational model of thrombosis is of great importance that decides the simulation performance. In the present study, a hybrid particle-continuum model with plasma, vascular wall, and thrombus being continuum material and platelets being discrete… read more here.
Keywords: model; level set; thrombus growth; computational model ... See more keywords
A dual role for the class III PI3K, Vps34, in platelet production and thrombus growth.
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood-2017-04-781641
Abstract: To uncover the role of Vps34, the sole class III phosphoinositide 3-kinase (PI3K), in megakaryocytes (MKs) and platelets, we created a mouse model with Vps34 deletion in the MK/platelet lineage (Pf4-Cre/Vps34lox/lox). Deletion of Vps34 in… read more here.
Keywords: dual role; class iii; thrombus growth; vps34 ... See more keywords
A three-dimensional multiscale model for the prediction of thrombus growth under flow with single-platelet resolution
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1009850
Abstract: Modeling thrombus growth in pathological flows allows evaluation of risk under patient-specific pharmacological, hematological, and hemodynamical conditions. We have developed a 3D multiscale framework for the prediction of thrombus growth under flow on a spatially… read more here.
Keywords: thrombus growth; growth; multiscale; prediction ... See more keywords
Proposal of an in vitro thrombus-growth model for evaluating anticoagulants.
Sign Up to like & getrecommendations! Published in 2022 at "Drug discoveries & therapeutics"
DOI: 10.5582/ddt.2022.01040
Abstract: The general anticoagulant evaluation requires high expense equipment, reagents, and space. Therefore, not all laboratories can perform research related to anticoagulant. In this study, we propose a novel simple method "in vitro thrombus-growth model" that… read more here.
Keywords: thrombus growth; growth; proposal vitro; growth model ... See more keywords
In vitro study about prevention of vascular reocclusion by low intensity ultrasonic irradiation.
Sign Up to like & getrecommendations! Published in 2022 at "Drug discoveries & therapeutics"
DOI: 10.5582/ddt.2022.01064
Abstract: For the treatment of acute ischemic stroke, the current standard of care is thrombolysis by the administration of intravenous (IV) recombinant tissue-type plasminogen activator (rt-PA). Although this approach is proven to be effective, reocclusion within… read more here.
Keywords: thrombus growth; reocclusion; low intensity; intensity ... See more keywords