Development of antibody-based assays for high throughput discovery and mechanistic study of antiviral agents against yellow fever virus
Sign Up to like & getrecommendations! Published in 2020 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2020.104907
Abstract: Abstract Despite the availability of a highly effective yellow fever virus (YFV) vaccine, outbreaks of yellow fever frequently occur in Africa and South America with significant mortality, highlighting the pressing need for antiviral drugs to… read more here.
Keywords: yellow fever; rna; antiviral agents; throughput discovery ... See more keywords
High-Throughput Discovery and Characterization of Human Transcriptional Effectors
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DOI: 10.1016/j.cell.2020.11.024
Abstract: Thousands of proteins localize to the nucleus; however, it remains unclear which contain transcriptional effectors. Here, we develop HT-recruit, a pooled assay where protein libraries are recruited to a reporter, and their transcriptional effects are… read more here.
Keywords: human transcriptional; characterization human; throughput discovery; transcriptional effectors ... See more keywords
High-Throughput Discovery and Evaluation of a General Catalytic Method for N-Arylation of Weakly Nucleophilic Sulfonamides.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b03380
Abstract: Through targeted high-throughput experimentation (HTE), we have identified the Pd/AdBippyPhos catalyst system as an effective and general method to construct densely functionalized N,N-diaryl sulfonamide motifs relevant to medicinal chemistry. AdBippyPhos is particularly effective for the… read more here.
Keywords: discovery evaluation; throughput; evaluation general; method ... See more keywords
High-throughput discovery of novel small-molecule inhibitors of acid Ceramidase
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2150183
Abstract: Abstract Ceramide has a key role in the regulation of cellular senescence and apoptosis. As Ceramide levels are lowered by the action of acid ceramidase (AC), abnormally expressed in various cancers, the identification of AC… read more here.
Keywords: discovery novel; acid ceramidase; high throughput; ceramidase ... See more keywords