Development of antibody-based assays for high throughput discovery and mechanistic study of antiviral agents against yellow fever virus
Sign Up to like & getrecommendations! Published in 2020 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2020.104907
Abstract: Abstract Despite the availability of a highly effective yellow fever virus (YFV) vaccine, outbreaks of yellow fever frequently occur in Africa and South America with significant mortality, highlighting the pressing need for antiviral drugs to… read more here.
Keywords: yellow fever; rna; antiviral agents; throughput discovery ... See more keywords
High-Throughput Discovery and Characterization of Human Transcriptional Effectors
Sign Up to like & getrecommendations! Published in 2020 at "Cell"
DOI: 10.1016/j.cell.2020.11.024
Abstract: Thousands of proteins localize to the nucleus; however, it remains unclear which contain transcriptional effectors. Here, we develop HT-recruit, a pooled assay where protein libraries are recruited to a reporter, and their transcriptional effects are… read more here.
Keywords: human transcriptional; characterization human; throughput discovery; transcriptional effectors ... See more keywords
High-Throughput Discovery and Evaluation of a General Catalytic Method for N-Arylation of Weakly Nucleophilic Sulfonamides.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b03380
Abstract: Through targeted high-throughput experimentation (HTE), we have identified the Pd/AdBippyPhos catalyst system as an effective and general method to construct densely functionalized N,N-diaryl sulfonamide motifs relevant to medicinal chemistry. AdBippyPhos is particularly effective for the… read more here.
Keywords: discovery evaluation; throughput; evaluation general; method ... See more keywords
High-Throughput Discovery Illuminates Design Principles and Limits for Long-Lived Charged Species in Organic Electrolytes.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.5c10140
Abstract: The chemical stability of charged molecules in all-organic redox flow batteries (RFBs) is required for the prolonged operation of these devices. Molecular engineering and electrolyte optimization are used to mitigate parasitic reactions and extend the… read more here.
Keywords: throughput discovery; high throughput; discovery illuminates; throughput ... See more keywords
High-throughput discovery of novel small-molecule inhibitors of acid Ceramidase
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2150183
Abstract: Abstract Ceramide has a key role in the regulation of cellular senescence and apoptosis. As Ceramide levels are lowered by the action of acid ceramidase (AC), abnormally expressed in various cancers, the identification of AC… read more here.
Keywords: discovery novel; acid ceramidase; high throughput; ceramidase ... See more keywords
High-Throughput Discovery and Electron-Doping Tuning of Superconducting Ternary Lithium Borides
Sign Up to like & getrecommendations! Published in 2025 at "Chinese Physics B"
DOI: 10.1088/1674-1056/ae27b1
Abstract: Incorporating another metal into binary metal borides has emerged as a highly effective strategy for optimizing material properties. Herein, Using high-throughput calculations, we systematically investigated the structural, electronic, and superconducting properties of Fm 3 m… read more here.
Keywords: lithium; high throughput; throughput discovery; electron doping ... See more keywords