Tethered primary hepatocyte spheroids on polystyrene multi-well plates for high-throughput drug safety testing
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-61699-4
Abstract: Hepatocyte spheroids are useful models for mimicking liver phenotypes in vitro because of their three-dimensionality. However, the lack of a biomaterial platform which allows the facile manipulation of spheroid cultures on a large scale severely… read more here.
Keywords: well plates; throughput drug; hepatocyte spheroids; polystyrene ... See more keywords
The impact of microfluidics in high-throughput drug-screening applications
Sign Up to like & getrecommendations! Published in 2022 at "Biomicrofluidics"
DOI: 10.1063/5.0087294
Abstract: Drug discovery is an expensive and lengthy process. Among the different phases, drug discovery and preclinical trials play an important role as only 5–10 of all drugs that begin preclinical tests proceed to clinical trials.… read more here.
Keywords: drug screening; screening applications; high throughput; throughput drug ... See more keywords
ATRT-22. HIGH-THROUGHPUT DRUG SCREENING OF FDA-APPROVED CANCER DRUGS REVEALS POTENTIAL THERAPEUTIC APPROACHES FOR ATYPICAL TERATOID RHABDOID TUMOUR
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaa222.021
Abstract: Abstract Atypical teratoid/rhabdoid tumors (ATRT), are the most common brain tumor in children under the age of 1 year with an overall survival of ~17%. Like extracranial rhabdoid tumors, ATRT is exclusively characterized by bi-allelic… read more here.
Keywords: throughput drug; teratoid rhabdoid; atypical teratoid; drug screening ... See more keywords
Abstract 195: Establishment and validation of pheochromocytoma organoids for high-throughput drug screening
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-195
Abstract: Pheochromocytomas and paragangliomas (PPGL) are rare catecholamine-secreting neuroendocrine tumors known for their genetic diversity. They can be categorized in discrete molecular subgroups, including tumors presenting with pseudohypoxia or kinase signaling activation. Metastatic and recurrent PPGLs… read more here.
Keywords: drug screening; high throughput; throughput drug; ppgl organoids ... See more keywords
The Lattice-Boltzmann Modeling of Microflows in a Cell Culture Microdevice for High-Throughput Drug Screening
Sign Up to like & getrecommendations! Published in 2021 at "Applied Sciences"
DOI: 10.3390/app11199140
Abstract: The aim of our research was to develop a numerical model of microflows occurring in the culture chambers (CC) of a microfluidic device of our construction for high-throughput drug screening. The incompressible fluid flow model… read more here.
Keywords: throughput drug; drug screening; lattice boltzmann; culture ... See more keywords