High-Throughput Screen Reveals the Structure–Activity Relationship of the Antimicrobial Lasso Peptide Ubonodin
Sign Up to like & getrecommendations! Published in 2022 at "ACS Central Science"
DOI: 10.1021/acscentsci.2c01487
Abstract: The Burkholderia cepacia complex (Bcc) is a group of bacteria including several opportunistic human pathogens. Immunocompromised individuals and cystic fibrosis patients are especially vulnerable to serious infections by these bacteria, motivating the search for compounds… read more here.
Keywords: structure activity; throughput screen; lasso peptide; high throughput ... See more keywords
High Throughput Screen Identifies Interferon γ-Dependent Inhibitors of Toxoplasma gondii Growth.
Sign Up to like & getrecommendations! Published in 2018 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.8b00135
Abstract: Toxoplasma gondii is an obligate intracellular parasite capable of causing severe disease due to congenital infection and in patients with compromised immune systems. Control of infection is dependent on a robust Th1 type immune response… read more here.
Keywords: throughput screen; control; infection; toxoplasma gondii ... See more keywords
Discovery of pan autophagy inhibitors through a high-throughput screen highlights macroautophagy as an evolutionarily conserved process across 3 eukaryotic kingdoms
Sign Up to like & getrecommendations! Published in 2017 at "Autophagy"
DOI: 10.1080/15548627.2017.1339002
Abstract: ABSTRACT Due to the involvement of macroautophagy/autophagy in different pathophysiological conditions such as infections, neurodegeneration and cancer, identification of novel small molecules that modulate the process is of current research and clinical interest. In this… read more here.
Keywords: throughput screen; process across; process; conserved process ... See more keywords
A high-throughput screen identifies small molecule modulators of alternative splicing by targeting RNA G-quadruplexes
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz036
Abstract: Abstract RNA secondary structures have been increasingly recognized to play an important regulatory role in post-transcriptional gene regulation. We recently showed that RNA G-quadruplexes, which serve as cis-elements to recruit splicing factors, play a critical… read more here.
Keywords: throughput screen; alternative splicing; rna quadruplexes; high throughput ... See more keywords
Metabolomics: A High-throughput Screen for Biochemical and Bioactivity Diversity in Plants and Crops.
Sign Up to like & getrecommendations! Published in 2018 at "Current pharmaceutical design"
DOI: 10.2174/1381612824666180515125926
Abstract: Plants and crops contain a staggering diversity of compounds, many of which have pharmacological activity towards a variety of diseases. These properties have been exploited by traditional and modern medicine providing important sources of healthcare… read more here.
Keywords: diversity; throughput screen; plants crops; discovery ... See more keywords