Thrown for a Loop: Awakening BORIS to Evade ALK Inhibition Therapy.
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DOI: 10.1016/j.ccell.2019.09.009
Abstract: Mechanisms of acquired resistance to ALK inhibition therapy in neuroblastoma have not yet been elucidated. In a recent issue of Nature, Debruyne et al. demonstrate that resistant MYCN-amplified ALK-mutated neuroblastoma cells overexpress BORIS, resulting in wide-ranging… read more here.
Keywords: alk inhibition; thrown loop; inhibition therapy; alk ... See more keywords