Comprehensively characterizing cellular changes and the expression of THSD7A and PLA2R1 under multiple in vitro models of podocyte injury
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DOI: 10.1002/cbf.3719
Abstract: The unique morphology and gene expression of podocytes are critical for kidney function, and their abnormalities lead to nephropathies such as diabetic nephropathy and membranous nephropathy. Podocytes cultured in vitro are valuable tools to dissect… read more here.
Keywords: pla2r1; cell; thsd7a; podocyte injury ... See more keywords
THSD7A as a marker for paraneoplastic membranous nephropathy
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DOI: 10.1007/s11255-018-02068-z
Abstract: The phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain containing 7A (THSD7A) are the two major autoantigens in primary membranous nephropathy (MN) [1, 2]. In particular, the THSD7A-associated MN may have a unique relationship with… read more here.
Keywords: antibody; pathology; malignancy; membranous nephropathy ... See more keywords
Human anti-thrombospondin type 1 domain-containing 7A antibodies induce membranous nephropathy through activation of lectin complement pathway
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DOI: 10.1042/bsr20180131
Abstract: To investigate whether the human anti-thrombospondin type 1 domain-containing 7A (THSD7A) antibody-induced membranous nephropathy (MN) is mediated by activating lectin complement pathway. Automatic biochemical apparatus was used to assess renal function of mice. The serum… read more here.
Keywords: complement pathway; lectin complement; thsd7a; human anti ... See more keywords
An Indirect Immunofluorescence Method Facilitates Detection of Thrombospondin Type 1 Domain-Containing 7A-Specific Antibodies in Membranous Nephropathy.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2016010050
Abstract: Thrombospondin type 1 domain-containing 7A (THSD7A) is a target antigen identified in adult membranous nephropathy (MN) along with the major antigen phospholipase A2 receptor 1 (PLA2R1). The prevalence of THSD7A-Ab-positive patients is unknown, and it… read more here.
Keywords: domain containing; type domain; thsd7a associated; membranous nephropathy ... See more keywords