Up-regulation of THY1 attenuates interstitial pulmonary fibrosis and promotes lung fibroblast apoptosis during acute interstitial pneumonia by blockade of the WNT signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Cell Cycle"
DOI: 10.1080/15384101.2019.1578144
Abstract: ABSTRACT Acute interstitial pneumonia (AIP) is an idiopathic pulmonary disease featuring rapid progressive dyspnea and respiratory failure. These symptoms typically develop within several days or weeks in patients without any pre-existing lung disease or external… read more here.
Keywords: thy1; apoptosis; lung fibroblast; pulmonary fibrosis ... See more keywords
Toward the Clinical Development and Validation of a Thy1-Targeted Ultrasound Contrast Agent for the Early Detection of Pancreatic Ductal Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Investigative Radiology"
DOI: 10.1097/rli.0000000000000697
Abstract: Supplemental digital content is available in the text. Objectives Early detection of pancreatic ductal adenocarcinoma (PDAC) represents the most significant step toward the treatment of this aggressive lethal disease. Previously, we engineered a preclinical Thy1-targeted… read more here.
Keywords: pdac; contrast agent; scfv; thy1 targeted ... See more keywords
Taxonomy of fibroblasts and progenitors in the synovial joint at single-cell resolution
Sign Up to like & getrecommendations! Published in 2022 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/ard-2021-221682
Abstract: Objectives Fibroblasts in synovium include fibroblast-like synoviocytes (FLS) in the lining and Thy1+ connective-tissue fibroblasts in the sublining. We aimed to investigate their developmental origin and relationship with adult progenitors. Methods To discriminate between Gdf5-lineage… read more here.
Keywords: thy1; cell; gdf5 lineage; fibroblasts progenitors ... See more keywords
Abstract 3909: THY1 regulates therapy resistance in glioblastoma recurrence
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3909
Abstract: Glioblastoma (GBM), is the most common primary brain tumor. It is a lethal disease with a median survival of 15 months characterized by treatment resistance, aggressive brain invasion, and inevitable recurrence. Less than 10 percent… read more here.
Keywords: thy1; glioblastoma; thy1 expression; recurrence ... See more keywords
1333 THY1 Upregulates Glioma Stem Cell Phenotype and Induces Treatment Resistance in Glioblastoma
Sign Up to like & getrecommendations! Published in 2025 at "Neurosurgery"
DOI: 10.1227/neu.0000000000003360_1333
Abstract: INTRODUCTION: Glioblastoma(GBM) is a lethal intracranial neoplasm that inevitably recurs despite treatment with DNA damaging therapies, radiation(RT) and temozolomide(TMZ). Recurrence is likely driven by inherently resistant glioma stem-like cells(GSCs), which have baseline upregulation of DNA… read more here.
Keywords: treatment; high thy1; dna repair; thy1 ... See more keywords
THY1 (CD90) Maintains the Adherens Junctions in Nasopharyngeal Carcinoma via Inhibition of SRC Activation
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15072189
Abstract: Simple Summary Nasopharyngeal carcinoma (NPC) is endemic to southern China and cancer metastasis remains the main cause of treatment failures. Previously we have found THY1, a cell surface glycoprotein, inhibits the invasion of NPC cells… read more here.
Keywords: thy1; cell; inhibition; invasion ... See more keywords
Single-Cell Sequencing Reveals the Heterogeneity of Hepatic Natural Killer Cells and Identifies the Cytotoxic Natural Killer Subset in Schistosomiasis Mice
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms26073211
Abstract: Schistosoma japonicum eggs in the host liver form granuloma and liver fibrosis and then lead to portal hypertension and cirrhosis, seriously threatening human health. Natural killer (NK) cells can kill activated hepatic stellate cells (HSCs)… read more here.
Keywords: cell sequencing; single cell; killer; natural killer ... See more keywords