Comparative analysis of thymic subpopulations during different modes of atrophy identifies the reactive oxygen species scavenger, N‐acetyl cysteine, to increase the survival of thymocytes during infection‐induced and lipopolysaccharide‐induced thymic atrophy
Sign Up to like & getrecommendations! Published in 2019 at "Immunology"
DOI: 10.1111/imm.13043
Abstract: The development of immunocompetent T cells entails a complex pathway of differentiation in the thymus. Thymic atrophy occurs with ageing and during conditions such as malnutrition, infections and cancer chemotherapy. The comparative changes in thymic… read more here.
Keywords: reactive oxygen; dex; infection; thymic atrophy ... See more keywords
Altered bone marrow lymphopoiesis and interleukin-6-dependent inhibition of thymocyte differentiation contribute to thymic atrophy during Trypanosoma cruzi infection
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DOI: 10.18632/oncotarget.14886
Abstract: Thymic atrophy occurs during infection being associated with apoptosis of double positive (DP) and premature exit of DP and double negative (DN) thymocytes. We observed for the first time that a significant bone marrow aplasia… read more here.
Keywords: differentiation; thymic atrophy; bone marrow;
Thymus, undernutrition, and infection: Approaching cellular and molecular interactions
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DOI: 10.3389/fnut.2022.948488
Abstract: Undernutrition remains a major issue in global health. Low protein-energy consumption, results in stunting, wasting and/or underweight, three deleterious forms of malnutrition that affect roughly 200 million children under the age of five years. Undernutrition… read more here.
Keywords: undernutrition; infection; thymic atrophy; cellular molecular ... See more keywords