AIRE illuminates the feature of medullary thymic epithelial cells in thymic carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Medicine"
DOI: 10.1002/cam4.5777
Abstract: Despite the clear distinction between cortical (cTECs) and medullary thymic epithelial cells (mTECs) in physiology, the cell of origin of thymic carcinomas (TCs) and other thymic epithelial tumors remained enigmatic. We addressed this issue by… read more here.
Keywords: thymic epithelial; tcs; aire illuminates; epithelial cells ... See more keywords
Understanding the landscape of immunotherapy in thymic epithelial tumors
Sign Up to like & getrecommendations! Published in 2023 at "Cancer"
DOI: 10.1002/cncr.34678
Abstract: Thymic epithelial tumors (TETs) are a rare group of malignancies arising from the thymus. Surgery remains the foundation of treatment for patients with early‐stage disease. Limited treatment options are available for the treatment of unresectable,… read more here.
Keywords: understanding landscape; immunotherapy thymic; thymic epithelial; landscape immunotherapy ... See more keywords
Inside Cover: Eur. J. Immunol. 2'17.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of immunology"
DOI: 10.1002/eji.201770029
Abstract: Our inside cover features immunofluorescent staining of a thymic epithelial cell colony that resulted from culturing E14.5 thymic epithelial progenitor cells in vitro for 6 days. This image was acquired using confocal microscopy, with cell… read more here.
Keywords: eur immunol; thymic epithelial; inside cover; cell ... See more keywords
An induced thymic epithelial cell‐based high throughput screen for thymus extracellular matrix mimetics
Sign Up to like & getrecommendations! Published in 2023 at "European Journal of Immunology"
DOI: 10.1002/eji.202249934
Abstract: Thymic epithelial cells (TECs) are key effectors of the thymic stroma and are critically required for T‐cell development. TECs comprise a diverse set of related but functionally distinct cell types that are scarce and difficult… read more here.
Keywords: cell; extracellular matrix; induced thymic; thymic epithelial ... See more keywords
T‐cell selection in the thymus: New routes toward the identification of the self‐peptide ligandome presented by thymic epithelial cells
Sign Up to like & getrecommendations! Published in 2023 at "European Journal of Immunology"
DOI: 10.1002/eji.202250202
Abstract: Within the thymus, thymic epithelial cells (TECs) provide a dedicated niche for the selection of functional T cells expressing a highly variable and self‐tolerant T‐cell receptor (TCR) repertoire. In this minireview, we start by summarizing… read more here.
Keywords: cell selection; thymic epithelial; self peptide; epithelial cells ... See more keywords
iTRAQ‐based proteomic analysis of 17β‐Estradiol‐induced anti‐proliferation and apoptosis in mouse thymic epithelial cells by disturbing ribosomal biogenesis
Sign Up to like & getrecommendations! Published in 2022 at "IUBMB Life"
DOI: 10.1002/iub.2674
Abstract: Many evidences have suggested that estrogen was associated with thymic atrophy and suppressed thymocyte functions. Thymic epithelial cells (TECs), as a crucial constituent of thymic stroma support a unique microenvironment for thymocyte maturation, but the… read more here.
Keywords: mtec1 cells; anti proliferation; apoptosis; thymic epithelial ... See more keywords
Proteomic analysis of zearalenone toxicity on mouse thymic epithelial cells
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4248
Abstract: Zearalenone (ZEA) is one of the most major food contaminants in cereal crops worldwide, risking health of both livestock and humans. This study aimed to assess the cytotoxicity and the underlying mechanism of ZEA on… read more here.
Keywords: analysis; differentially expressed; zearalenone; toxicity ... See more keywords
Isolation of Highly Viable Thymic Epithelial Cells for Use in In Vitro and In Vivo Experiments.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8938-6_11
Abstract: Thymic epithelial cells (TECs) play multiple essential roles in T-cell development and the establishment of immune tolerance, but their isolation can be challenging, and their low viability upon isolation complicates downstream experiments. A method that… read more here.
Keywords: epithelial cells; isolation highly; highly viable; biology ... See more keywords
Using CT to evaluate mediastinal great vein invasion by thymic epithelial tumors: measurement of the interface between the tumor and neighboring structures
Sign Up to like & getrecommendations! Published in 2021 at "European Radiology"
DOI: 10.1007/s00330-021-08276-z
Abstract: For thymic epithelial tumors, simple contact with adjacent structures does not necessarily mean invasion. The purpose of our study was to develop a simple noninvasive technique for evaluating organ invasion using routine pretreatment computed tomography… read more here.
Keywords: mediastinal great; invasion; tumor neighboring; thymic epithelial ... See more keywords
RelB intrinsically regulates the development and function of medullary thymic epithelial cells
Sign Up to like & getrecommendations! Published in 2017 at "Science China Life Sciences"
DOI: 10.1007/s11427-017-9298-3
Abstract: Medullary thymic epithelial cells (mTECs) act as one of the major stromal components in the thymus for selection and maturation of both conventional T cells and non-conventional T cells. Extensive efforts have been spent to… read more here.
Keywords: epithelial cells; relb; thymic epithelial; development function ... See more keywords
Immunoproteasomes Control the Homeostasis of Medullary Thymic Epithelial Cells by Alleviating Proteotoxic Stress.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.10.121
Abstract: The sole nonredundant role of the thymic medulla is to induce central tolerance, a vital process that depends on promiscuous gene expression (pGE), a unique feature of medullary thymic epithelial cells (mTECs). Although pGE enhances… read more here.
Keywords: homeostasis; epithelial cells; mtecs; proteotoxic stress ... See more keywords