Role of thymus in health and disease.
Sign Up to like & getrecommendations! Published in 2022 at "International reviews of immunology"
DOI: 10.1080/08830185.2022.2064461
Abstract: The thymus is a primary lymphoid organ, essential for the development of T-cells that will protect from invading pathogens, immune disorders, and cancer. The thymus decreases in size and cellularity with age referred to as… read more here.
Keywords: thymic involution; cell; thymus health; involution ... See more keywords
Age‐related loss of intestinal barrier integrity plays an integral role in thymic involution and T cell ageing
Sign Up to like & getrecommendations! Published in 2024 at "Aging Cell"
DOI: 10.1111/acel.14401
Abstract: The intestinal epithelium serves as a physical and functional barrier against harmful substances, preventing their entry into the circulation and subsequent induction of a systemic immune response. Gut barrier dysfunction has recently emerged as a… read more here.
Keywords: age; cell ageing; barrier; age related ... See more keywords
Distribution of Ectopic Germinal Centers in Thymic Epithelial Tumors and Their Relationship With Thymic Involution
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DOI: 10.1111/cas.70183
Abstract: Ectopic germinal centers (GCs) are often formed in the thymus of patients with anti‐acetylcholine receptor antibody (anti‐AChR Ab)‐positive thymic epithelial tumors (TETs) and are considered sites where B cells undergo affinity maturation to produce high‐affinity… read more here.
Keywords: thymic involution; thymic epithelial; ectopic germinal; anti achr ... See more keywords
A Proposed Link Between Acute Thymic Involution and Late Adverse Effects of Chemotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.933547
Abstract: Epidemiologic data suggest that cancer survivors tend to develop a protuberant number of adverse late effects, including second primary malignancies (SPM), as a result of cytotoxic chemotherapy. Besides the genotoxic potential of these drugs that… read more here.
Keywords: cell; thymic involution; chemotherapy; tumor ... See more keywords
Systemic immunostimulation induces glucocorticoid-mediated thymic involution succeeded by rebound hyperplasia which is impaired in aged recipients
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2024.1429912
Abstract: The thymus is the central organ involved with T-cell development and the production of naïve T cells. During normal aging, the thymus undergoes marked involution, reducing naïve T-cell output and resulting in a predominance of… read more here.
Keywords: glucocorticoid mediated; mediated thymic; cell; involution ... See more keywords
Aging-dependent immunological changes in multiple sclerosis
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2025.1663526
Abstract: Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease in which immune dysregulation plays a central role. As the life expectancy of people with MS (pwMS) increases, understanding how aging affects their immune system—collectively… read more here.
Keywords: age; multiple sclerosis; age related; pwms ... See more keywords
Transcriptome analysis reveals a potential regulatory mechanism of the lnc-5423.6/IGFBP5 axis in the early stages of mouse thymic involution
Sign Up to like & getrecommendations! Published in 2023 at "Acta Biochimica et Biophysica Sinica"
DOI: 10.3724/abbs.2023042
Abstract: Age-related thymic involution is one of the significant reasons for induced immunity decline. Recent evidence has indicated that lncRNAs are widely involved in regulating organ development. However, the lncRNA expression profiles in mouse thymic involution… read more here.
Keywords: lnc 5423; thymic involution; mouse thymic; involution ... See more keywords