Identification of a genomic enhancer that enforces proper apoptosis induction in thymic negative selection
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DOI: 10.1038/s41467-019-10525-1
Abstract: During thymic negative selection, autoreactive thymocytes carrying T cell receptor (TCR) with overtly strong affinity to self-MHC/self-peptide are removed by Bim-dependent apoptosis, but how Bim is specifically regulated to link TCR activation and apoptosis induction… read more here.
Keywords: negative selection; thymic negative; apoptosis induction; apoptosis ... See more keywords