Multimodal human thymic profiling reveals trajectories and cellular milieu for T agonist selection
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DOI: 10.3389/fimmu.2022.1092028
Abstract: To prevent autoimmunity, thymocytes expressing self-reactive T cell receptors (TCRs) are negatively selected, however, divergence into tolerogenic, agonist selected lineages represent an alternative fate. As thymocyte development, selection, and lineage choices are dependent on spatial… read more here.
Keywords: thymic profiling; cell; multimodal human; human thymic ... See more keywords