Attenuation of apoptotic cell detection triggers thymic regeneration after damage.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109789
Abstract: The thymus, which is the primary site of TÂ cell development, is particularly sensitive to insult but also has a remarkable capacity for repair. However, the mechanisms orchestrating regeneration are poorly understood, and delayed repair is… read more here.
Keywords: regeneration; apoptotic cell; thymic regeneration; damage ... See more keywords
Radiation inducible MafB gene is required for thymic regeneration
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-89836-7
Abstract: The thymus facilitates mature T cell production by providing a suitable stromal microenvironment. This microenvironment is impaired by radiation and aging which lead to immune system disturbances known as thymic involution. Young adult thymus shows… read more here.
Keywords: mafb; thymus; thymic regeneration; radiation inducible ... See more keywords
Restored Thymic Output after Androgen Blockade Participates in Antitumor Immunity.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of immunology"
DOI: 10.4049/jimmunol.2200696
Abstract: The thymus is a hormone-sensitive organ, which involutes with age in response to production of sex steroids. Thymic involution leads to a decrease in the generation of recent thymic emigrants (RTEs), resulting in a reduced… read more here.
Keywords: thymic regeneration; restored thymic; output; response ... See more keywords