Multilevel virtual screening approach for discovery of thymidine phosphorylase inhibitors as potential anticancer agents
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.131648
Abstract: Abstract Thymidine phosphorylase (TP) is an enzyme which catalyses the conversion of thymidine to thymine and 2-deoxy-α- d -ribose-1-phosphate. The 2-deoxy-α- d -ribose-1-phosphate is then dephosphorylated to the 2-deoxy-α- d -ribose, which can promote angiogenesis,… read more here.
Keywords: thymidine phosphorylase; virtual screening; thymidine; multilevel virtual ... See more keywords
Evaluation of Thymidine Phosphorylase Inhibitors in Glioblastoma and Their Capacity for Temozolomide Potentiation.
Sign Up to like & getrecommendations! Published in 2021 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.1c00494
Abstract: A number of studies have shown high levels of thymidine phosphorylase (TP) expression in glioblastoma (GBM), with trace or undetectable TP levels in normal developed brain tissue. TP catalyzes the reversible phosphorolysis of thymidine to… read more here.
Keywords: thymidine phosphorylase; thymidine; inhibitors glioblastoma; evaluation thymidine ... See more keywords
Protective Effect of Thymidine on DNA Damage Induced by Hydrogen Peroxide in Human Hepatocellular Cancer Cells
Sign Up to like & getrecommendations! Published in 2020 at "ACS Omega"
DOI: 10.1021/acsomega.0c02843
Abstract: Intracellular ribonucleotide (RN) and deoxyribonucleotide (dRN) pool sizes are critical for the fidelity of DNA synthesis. They are likely to be severely perturbed by many factors which disrupt the integrity and stability of DNA, leading… read more here.
Keywords: dna damage; thymidine; hydrogen peroxide; damage ... See more keywords
DNA-Protein Cross-Linking Sequencing for Genome-Wide Mapping of Thymidine Glycol.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c10490
Abstract: Thymidine glycol (Tg) is the most prevalent form of oxidatively induced pyrimidine lesions in DNA. Tg can arise from direct oxidation of thymidine in DNA. In addition, 5-methyl-2'-deoxycytidine (5-mdC) can be oxidized to 5-mdC glycol,… read more here.
Keywords: dna; wide mapping; thymidine; glycol ... See more keywords
Thymidine utilisation pathway is a novel phenotypic switch of Mycoplasma hominis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Microbiology"
DOI: 10.1099/jmm.0.001468
Abstract: Introduction Mycoplasma hominis is a bacterium belonging to the class Mollicutes . It causes acute and chronic infections of the urogenital tract. The main features of this bacterium are an absence of cell wall and… read more here.
Keywords: phosphate; hominis; thymidine; energy ... See more keywords
Quantification of Urinary Thymidine Dimers in Volunteers After Ultraviolet Radiation Using a New UPLC-MS/MS-based Method
Sign Up to like & getrecommendations! Published in 2022 at "AntiCancer Research"
DOI: 10.21873/anticanres.16015
Abstract: Background/Aim: Solar ultraviolet radiation (UVR) is a carcinogen and irradiation of the skin results in DNA damage. Cyclobutane pyrimidine dimers (CPDs), including thymidine dimers, are among the most frequent forms of DNA damage. When CPDs… read more here.
Keywords: thymidine; thymidine dimers; based method; ultraviolet radiation ... See more keywords
Increased Cytotoxicity of Herpes Simplex Virus Thymidine Kinase Expression in Human Induced Pluripotent Stem Cells
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20040810
Abstract: Human induced pluripotent stem cells (iPSCs) hold enormous promise for regenerative medicine. The major safety concern is the tumorigenicity of transplanted cells derived from iPSCs. A potential solution would be to introduce a suicide gene… read more here.
Keywords: thymidine; human induced; expression; pluripotent stem ... See more keywords