Deoxynucleoside Therapy for Thymidine Kinase 2–Deficient Myopathy
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Neurology"
DOI: 10.1002/ana.25506
Abstract: Thymidine kinase 2, encoded by the nuclear gene TK2, is required for mitochondrial DNA maintenance. Autosomal recessive TK2 mutations cause depletion and multiple deletions of mtDNA that manifest predominantly as a myopathy usually beginning in… read more here.
Keywords: deficient myopathy; kinase; kinase deficient; deoxynucleoside therapy ... See more keywords
Synergistic Deoxynucleoside and Gene Therapies for Thymidine Kinase 2 Deficiency
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Neurology"
DOI: 10.1002/ana.26185
Abstract: Autosomal recessive human thymidine kinase 2 (TK2) mutations cause TK2 deficiency, which typically manifests as a progressive and fatal mitochondrial myopathy in infants and children. Treatment with pyrimidine deoxynucleosides deoxycytidine and thymidine ameliorates mitochondrial defects… read more here.
Keywords: synergistic deoxynucleoside; therapy; gene; deficiency ... See more keywords
Thymidine Kinase PET Reporter Gene Imaging of Cancer Cells In Vivo.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7860-1_11
Abstract: Positron emission tomography (PET) is a three dimensional imaging modality that detects the accumulation of radiolabeled isotopes in vivo. Ectopic expression of a thymidine kinase reporter gene allows for the specific detection of reporter cells… read more here.
Keywords: reporter; cells vivo; pet; pet reporter ... See more keywords
Stepwise characterization of non-synonymous mutations in the HSV-1 thymidine kinase gene by different functional assays.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of virological methods"
DOI: 10.1016/j.jviromet.2017.05.013
Abstract: Twenty amino acid substitutions in the thymidine kinase (TK) of clinical herpes simplex virus type 1 strains were assessed for conferring acyclovir (ACV) resistance. Site-directed mutagenesis, cell-free protein synthesis and protein expression in Escherichia coli… read more here.
Keywords: stepwise characterization; activity towards; characterization non; activity ... See more keywords
Deletion of the thymidine kinase gene attenuates Caprine alphaherpesvirus 1 in goats.
Sign Up to like & getrecommendations! Published in 2019 at "Veterinary microbiology"
DOI: 10.1016/j.vetmic.2019.07.022
Abstract: Caprine alphaherpesvirus 1 (CpHV-1) is a pathogen associated with systemic infection and respiratory disease in kids and subclinical infection or reproductive failure and abortions in adult goats. The enzyme thymidine kinase (TK) is an important… read more here.
Keywords: caprine alphaherpesvirus; cphv; gene; virus ... See more keywords
Efficient establishment of reactivatable latency by an acyclovir-resistant herpes simplex virus 1 thymidine kinase substitution mutant with reduced neuronal replication.
Sign Up to like & getrecommendations! Published in 2021 at "Virology"
DOI: 10.1016/j.virol.2021.01.016
Abstract: Herpes simplex virus 1 causes recurrent diseases by reactivating from latency, which requires the viral thymidine kinase (TK) gene. An acyclovir-resistant mutation in TK, V204G, was previously repeatedly identified in a patient with recurrent herpetic… read more here.
Keywords: latency; herpes simplex; simplex virus; replication ... See more keywords
Aptamer-Based Sandwich Assay for Measurement of Thymidine Kinase 1 in Serum of Cancerous Patients.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b01284
Abstract: Thymidine kinase 1 (TK1) is traditionally a serum biomarker that is elevated in the early stages of malignancies. The diagnostic and prognostic role of TK1 for screening and monitoring human malignancies has recently been investigated.… read more here.
Keywords: sandwich assay; cancerous patients; tk1; aptamer ... See more keywords
Plasma thymidine kinase activity as a prognostic biomarker in pancreatic ductal adenocarcinoma: a single-center prospective study.
Sign Up to like & getrecommendations! Published in 2023 at "Scandinavian journal of gastroenterology"
DOI: 10.1080/00365521.2023.2198057
Abstract: BACKGROUND Pancreatic ductal adenocarcinoma (PDAC) patients might benefit from a biomarker to more precisely prognosticate their overall survival to make more informed treatment and surveillance decisions. The aim of the study was to assess the… read more here.
Keywords: biomarker; ductal adenocarcinoma; activity; thymidine kinase ... See more keywords
Preoperative Serum Thymidine Kinase Activity as Novel Monitoring, Prognostic, and Predictive Biomarker in Pancreatic Cancer
Sign Up to like & getrecommendations! Published in 2018 at "Pancreas"
DOI: 10.1097/mpa.0000000000000966
Abstract: Objective The aim of the study was to investigate serum thymidine kinase 1 (S-TK) activity as a diagnostic and prognostic marker for patients with pancreatic ductal adenocarcinoma (PDAC). Methods Using the sensitive TK activity assay… read more here.
Keywords: kinase activity; serum thymidine; preoperative serum; activity ... See more keywords
Deoxynucleoside therapy for respiratory involvement in adult patients with thymidine kinase 2-deficient myopathy
Sign Up to like & getrecommendations! Published in 2020 at "BMJ Open Respiratory Research"
DOI: 10.1136/bmjresp-2020-000774
Abstract: Background Recessive mutations in the thymidine kinase 2 (TK2) gene cause a rare mitochondrial myopathy, frequently with severe respiratory involvement. Deoxynucleoside therapy is currently under investigation. Research question What is the impact of nucleosides in… read more here.
Keywords: respiratory; respiratory involvement; deoxynucleoside therapy; thymidine kinase ... See more keywords
Late-onset thymidine kinase 2 deficiency: a review of 18 cases
Sign Up to like & getrecommendations! Published in 2019 at "Orphanet Journal of Rare Diseases"
DOI: 10.1186/s13023-019-1071-z
Abstract: BackgroundTK2 gene encodes for mitochondrial thymidine kinase, which phosphorylates the pyrimidine nucleosides thymidine and deoxycytidine. Recessive mutations in the TK2 gene are responsible for the ‘myopathic form’ of the mitochondrial depletion/multiple deletions syndrome, with a… read more here.
Keywords: late onset; muscle; deficiency; thymidine kinase ... See more keywords